A randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of esomeprazole once daily for the treatment of gastroesophageal reflux disease (GERD) in neonatal patients, including premature and up to 1 month corrected age The primary objective of this study is to assess the difference between esomeprazole and placebo in the treatment of signs and symptoms of GERD as observed by 8-hour video and cardiorespiratory monito...

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A clinical trial to assess the efficacy and safety of aclidinium bromide 400 mcg/formoterol fumarate 12 mcg combination taken twice daily compared with each individual component (aclidinium bromide 400 mcg twice daily and formoterol fumarate 12 mcg twice daily) and tiotropium 18 mcg once daily when administered to patients with stable chronic obstructive pulmonary disease. Ensayo Ccínico para evaluar la eficacia y seguridad de una combinación de bromuro de aclidinio 400 mcg/formoterol fumarato 12 mcg tomadas dos veces/día comparada con cada componente individual (bromuro de aclidinio 400 mcg dos veces/día y formoterol fumarato 12 mcg dos veces/día) y tiotropio 18 mcg una vez al día cuando se administra a pacientes con enfermedad pulmonar obstructiva crónica estable Primary Objective for EU: To assess the non-inferior bronchodilation of AB 400 ?g BID as compared to TIO 18 ?g QD in COPD patients. Primary Objectives for USA: To assess the bronchodilatory effect o...

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Effects of a three-month course of rosuvastatin in patients with Systemic Lupus Erythematosus Not provided at time of registration

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Étude D419EC00001 : étude de phase 1-2, non randomisée, évaluant la sécurité, la tolérance et l’efficacité préliminaire du durvalumab en monothérapie associé à du trémélimumab chez des patients pédiatriques ayant des tumeurs solides avancées et des malignités hématologiques. Les tumeurs solides sont l’ensemble des cancers qui se développent à partir d’une tumeur localisée : peau, muqueuses, os, organes, etc. Ce sont les plus fréquentes puisqu’elles représentent 90% des ca...

• Pays France
• Organes Tumeurs solides, Tout cancer hématologique
• Spécialités Immunothérapie - Vaccinothérapie, Pédiatrie

A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study to Evaluate the Effect of Tesaglitazar 1 mg once daily on the Pharmacokinetics of Metformin Following Addition of Tesaglitazar to Metformin Treatment twice daily in Patients with Type 2 Diabetes To compare the effect of 1 mg tesaglitazar once daily versus placebo once daily given as add?on therapy to metformin on the steady state exposure (AUCss) of metformin in patients with type 2 diabetes ...

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A Phase II, Double-Blind, Placebo Controlled, Randomised Study To Assess The Efficacy And Safety Of 2 Doses Of ZACTIMA (ZD6474) In Combination With FOLFOX vs FOLFOX Alone For The Treatment Of Colorectal Cancer In Patients Who Have Failed Therapy With An Irinotecan And Fluoropyrimidine Containing Regimen The primary objective of this study is to assess the efficacy of ZD6474 (100 mg and 300 mg) in combination with the modified FOLFOX 6 regimen (mFOLFOX6) versus mFOLFOX6 alone for the treatment of pati...

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A randomised, open, phase IV, parallel group multicentre study to evaluate a change of management in Gastroesophageal Reflux Disease (GERD) patients by treatment with esomeprazole 40 mg or any other Proton Pump Inhibitor (PPI), after initial treatment failure, in ordinary clinical practice during 4 weeks The primary objective of this study is to assess how PPI treated GERD-patients with insufficient symptom control will benefit from a change in management by providing a more efficient acid secretion i...

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A Phase 2a, double blind, placebo controlled study to evaluate the efficacy of MEDI-563 in subjects with moderate to severe COPD and sputum eosinophilia The primary objective of this study is to evaluate the effect of multiple subcutaneous (SC) doses of MEDI-563 on the rate of moderate-to-severe acute axacerbations in Chronic Obstructive Pulmonary Dis...

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A Phase III, Randomized, Double-Blinded, Multi-Centre Study to Assess the Efficacy of Docetaxel (TAXOTERE™) in Combination with ZD6474 (ZACTIMA™) versus Docetaxel (TAXOTERE™) in combination with Placebo in Patients With Locally Advanced or Metastatic (Stage IIIb – IV) Non-small Cell Lung Cancer (NSCLC) after Failure of 1st Line Anti-Cancer Therapy The primary objective of this study is to demonstrate an improvement in PFS in the combination of ZACTIMA with docetaxel compared with docetaxel plus placebo in patients with locally advanced or metas...

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A Safety Extension Study with Benralizumab (MEDI-563) for Asthmatic Adults on Inhaled Corticosteroid Plus LABA Ensayo de extensión de seguridad con benralizumab (MEDI-563) en adultos asmáticos con un corticosteroide inhalado más LABA To assess the safety and tolerability of 2 dosing regimens of benralizumab for adult patients Evaluar la seguridad y la tolerabilidad de 2 pautas posológicas de benralizumab en pacientes adultos

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