Laser compared to topical medicine as primary treatment for glaucoma in Africa Background and study aims Glaucoma is an eye condition which develops when a fluid inside the eye (called the aqueous humour) cannot drain properly, causing pressure to build up that can result in da...

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Comparison of rivaroxaban (Xarelto®; Bayer HealthCare), fixed-dose oral anticoagulant (blood thinner), versus warfarin in patients with antiphospholipid syndrome (called APS), with or without 'lupus' (systemic lupus erythematosus) The primary aim of the trial is to assess whether the anticoagulant effects of rivaroxaban are not inferior to those of warfarin. This will be achieved by comparing the percentage change in endogenous...

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EXCITE: Erbitux, Xeloda, Campto, Irradiation Then Excision for locally advanced rectal cancer. (North West Clinical Oncology Group-04 on behalf of the NCRI rectal cancer subgroup) In a phase II setting in MRI-defined locally advanced rectal cancer to assess the downstaging effectiveness of preoperative chemoradiotherapy using capecitabine/ irinotecan/cetuximab plus radiotherapy...

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A RANDOMISED CONTROLLED TRIAL TO STUDY THE SIDE EFFECT PROFILE AND TO ESTABLISH MEASURES OF EFFICACY USING PHOTOFRIN OR 5 AMINOLAEVULINIC ACID PHOTODYNAMIC THERAPY IN THE ERADICATION OF DYSPLASIA IN BARRETT’S COLUMNAR LINED OESOPHAGUS The main aim of this single centre RCT is to determine whether Photodynamic therapy for high grade dysplasia in Barrrett's oesophagus using ALA has less side effects than Photofrin. Primary End Poin...

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A Pilot study of Response to Velcade combination chemotherapy in AL amyloidosis (REVEAL) The REVEAL Trial aims to assess the efficacy, safety and tolerability of two bortezomib-based combination chemotherapy regimens: VD (bortezomib [Velcade], and dexamethasone) and CVD (cyclophosphamide...

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TB Reach 5: to compare the efficacy of video observed treatment (VOT) versus directly observed treatment (DOT) in supporting adherence in patients with active tuberculosis Background and study aims Tuberculosis (TB) control is founded on the basis of early diagnosis to reduce the risk of onward transmission to others, and the patient completing an effective course of tr...

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A study of treatment for polyarteritis nodosa in children Estudio del tratamiento de la poliarteritis nodosa juvenil Is mycophenelate mofetil (MMF) as effective as cyclophosphamide (CYC) at inducing remission in children with polyarteritis nodosa (PAN)? Es el micofenolato mofetil (MMF) tan efectivo como la cic...

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A randomised phase II double blind placebo controlled trial of Whole Brain Radiotherapy (WBRT) and Tarceva (OSI-774, erlotinib) in patients with advanced non-small cell lung cancer (NSCLC) with multiple brain metastases To estimate the effect on neurological progression-free survival at 2 months (n = neurological progression or death) of WBRT, with concomitant Tarceva compared to WBRT alone in patients with advanced ...

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Effectiveness and cost effectiveness of early initiation and longer duration of emergency/seasonal unconditional cash transfers on children’s nutritional status in Tahoua, Niger Background and study aims Concern Worldwide (also see http://www.actionagainsthunger.org /) has been implementing unconditional cash transfers (UCT) as part of their humanitarian intervention during...

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Transplantation of umbilical cord blood (UCB) from unrelated donors (URD) in patients with haematological diseases using a reduced intensity conditioning regimen To validate the safety and efficacy of umbilical cord blood transplantation using a reduced intensity preparative regimen in patients with disorders of the blood using the approach developed by the Un...

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