Drivers of eating behaviour during chronic overconsumption Not provided at time of registration

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IntAct- IFA to prevent anastomotic leak in rectal cancer surgery Lay summary under review with external organisation

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STAR: A Randomised Multi-Stage Phase II/III trial of Sunitinib comparing Temporary cessation with Allowing continuation, at the time of maximal radiological response, in the first-line treatment of locally advanced and/or metastatic Renal cancer The aim of the STAR trial is to evaluate the use of a Modified sunitinib schedule compared to the Standard sunitinib schedule, in patients with locally advanced and/or metastatic renal cancer. The tri...

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Cyclophosphamide and dexamethasone in combination with Ixazomib, in relapsed or refractory multiple myeloma (RRMM) patients who have relapsed after treatment with thalidomide, lenolidomide and bortezomib https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-of-cyclophosphamide-dexamethasone-and-ixazomib-for-myeloma-muk-8

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ED95 doses of commonly used local anaesthetic agents for ultrasound guided brachial plexus blocks To find out the doses (of the most commonly used local anaesthetic agents)that have 95% chance of success for ultrasound guided brachial plexus blocks in patients scheduled for upper limb surgery. (...

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A Prospective, Single-centre, Randomised Study Evaluating the Clinical, Imaging and Immunological Depth of Remission Achieved by Very Early versus Delayed Etanercept in patients with Rheumatoid Arthritis (VEDERA) The main aim of the study is compare remission (absence of symptoms and signs of arthritis) achieved with very early etanercept therapy to that achieved by current standard care (methotrexate and a tr...

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ASPIRE 2: Action to Support Practices Implementing Research Evidence Plain English summary under review

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Carfilzomib in combination with doxorubicin and dexamethasone (CAD) therapy in transplant eligible relapsed myeloma patients Not provided at time of registration

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A phase II/III trial to assess the use of obinutuzmab against no treatment in patients who have recently had a good response to previous treatment for Chronic Lymphocytic Leukaemia (CLL) The principal research question this trial aims to answer is does obinutuzumab given within 3-12 months following a good response to prior treatment for chronic lymphocytic leukaemia (CLL) improve the...

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The impact of vitamin D supplementation in chronic heart failure Not provided at time of registration

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