Woman Man
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Extract
Determine the sixteen (16) week progression-free survival (PFS) rate for HKI-272 in women with advanced breast cancer.
Inclusion criteria
- Breast cancer is the most frequently diagnosed malignancy and the second most common cause of cancer related deaths in women. HER2 is a member of the epidermal growth factor receptor (EGFR) family that includes EGFR/HER1, HER2, HER3 and HER4, all being receptor tyrosine-protein kinases. The oncogenic role of HER2 has been extensively documented in breast cancer, where it is overexpressed in 25% to 30% of breast cancers