To Compare Blood and Urine Concentrations of Mirabegron (YM178) in Healthy Poor or Extensive Metabolizers for CYP2D6 and to Assess the Effect of Mirabegron on the Metabolism of Metoprolol The study aims to compare blood and urine concentrations of mirabegron (YM178) in healthy poor or extensive metabolizers for CYP2D6 and to evaluate if blood levels of metoprolol change whi...

• Country None
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A Study Evaluating Intermittent and Continuous OSI-906 and Weekly Paclitaxel in Patients With Recurrent Epithelial Ovarian Cancer (and Other Solid Tumors) This is a multi-center, randomized, open-label, phase 1/2 study of continuous weekly paclitaxel and escalating doses of intermittent or continuous OSI-906 in patients with recurrent/relaps...

• Country None
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A Study to Assess the Safety and Efficacy of Alefacept in Kidney Transplant Recipients A study to assess the safety and efficacy of Alefacept in de novo kidney transplant patients.

• Country None
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To Evaluate if Multiple Doses of Ketoconazole Change the Blood Concentration of YM150 (Darexaban) The primary objective of this study is to determine the effect of ketoconazole on the blood concentrations of darexaban and its metabolites (drug degradation products). The secondary objec...

• Country None
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Does Follow-up With Serum Beta Human Chorionic Gonadotropin (BhCG) Simplify Medical Abortion? The purpose of this study is to evaluate if BhCG testing to determine the completion of medical abortion simplifies the medical abortion protocol. Investigators hypothesize that women rand...

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To Evaluate Whether Naproxen and Darexaban (YM150) Interact in Their Effects The primary objective of this study is to evaluate whether naproxen and darexaban which have different effects on blood coagulation influence each other in their effects. Also it will be i...

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Cervical Preparation Before Dilation and Evacuation The purpose of this research study is to compare three different ways of opening a woman's cervix before her second-trimester surgical abortion. - Osmotic dilators: small rods that, wh...

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An Exploratory Study to Investigate Bladder Contractions in the Storage Phase and Related Bladder Sensations in Healthy Females and Females With Overactive Bladder (OAB) Using High Resolution and Conventional Urodynamics This study aims to identify differences in bladder contractions during the storage phase (non voiding activities) between OAB subjects and healthy subjects, using high resolution urodynami...

• Country Netherlands
• organs None
• Specialty None

Human Chorionic Gonadotropin (hCG) Trend After Medication Abortion This project will be a prospective physiologic study. We will closely follow 60 medication abortion patients with serial repeat serum hCG and urine semi-quantitative hCG testing. We plan t...

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A Study of BCI-838 and Several BCI-632 Prodrugs in Healthy Volunteers This study will evaluate the safety, tolerability and pharmacokinetics of BCI-838, its metabolite BCI-632 and several new pro-drugs in healthy male subjects.

• Country None
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• Specialty None