A Randomized, Controlled, Open-Label Comparison Study of the Efficacy and Safety of Slow Transitioning compared with Fast Transitioning from a Stimulant Medication to Atomoxetine in Pediatric and Adolescent Outpatients with DSM-IV Attention-Deficit/Hyperactivity Disorder (ADHD) The primary objective of the study is to compare the efficacy of 2 different switching approaches; at the end of the fast (Week 2) and slow (Week 10) transition from stimulants to atomoxetine as measu...

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A Randomized, Double-Blind, PLacebo-Controlled, Parallel Study to Assess the Efficacy and Safety of Tadalafil (LY450190) Once a Day in Subjects With Erectile Dysfunction Who Are Naive to PDE5 Inhibitors - To evaluate the efficacy of tadalafil 5 mg (with possible down-titration to 2.5 mg) compared with placebo, when taken orally once a day over 12 weeks, in improving erectile function in men with ED w...

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An Open-label, Single Arm, Phase 2 Study of Rituximab, Gemcitabine, and Oxaliplatin plus Oral Enzastaurin as Treatment for Patients with Relapsed Diffuse Large B-Cell Lymphoma Main objective : evaluation of progression free survival on R-GEMOX and enzastaurin, 1 year after treatment start, in patients with relapsed DLBCL or transformed (CD20+) indolent lymphoma, who are ol...

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F1D-MC-HGLQ A Randomized, Open-Label Study Comparing the Effects of Olanzapine Pamoate Depot with Oral Olanzapine on Treatment Outcomes in Outpatients with Schizophrenia The primary objective of the study F1D-MC-HGLQ is to assess the time to all-cause discontinuation in outpatients with schizophrenia who are at risk for relapse, as demonstrated by at least two episode...

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A Randomized Phase 3 Study of Enzastaurin versus Lomustine in the Treatment of Recurrent, Intracranial Glioblastoma Multiforme The primary objective is to compare enzastaurin versus lomustine in terms of PFS time in patients with recurrent, intracranial GBM (WHO Stage IV).

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A Phase 3b,randomized,double-blind,placebo-controlled parallel-design study to evaluate the efficacy and safety of tadalafil coadministered with finasteride for 6 months in men with lower urinary tract symptoms(LUTS) and prostatic enlargement secondary to benign prostatic hyperplasia(BPH) The primary objective of this study is to test the hypothesis that tadalafil 5 mg once daily co-administered with finasteride is superior to placebo once daily co-administered with finasteride for 12 ...

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Impact of Tadalafil (LY450190) Once a Day or Tadalafil On Demand Compared to Sildenafil Citrate On Demand on Treatment Discontinuation in Patients with Erectile Dysfunction who are Naïve to PDE5 Inhibitors The primary objective of this study is to assess the impact of tadalafil once a day (OaD) and tadalafil on demand (PRN) compared with sildenafil citrate PRN, in men with erectile dysfunction (ED) who ...

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A Randomised Phase 3 Trial of Alimta (pemetrexed) and Carboplatin versus Etoposide and Carboplatin in Extensive-Stage Small Cell Lung Cancer The primary objective of the study is to compare the overall survival of previously untreated patients with ED-SCLC after treatment with pemetrexed plus carboplatin versus etoposide plus carboplatin.

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Effect of Duloxetine on Valsalva Leak Point Pressure and Quantitative Rhabdosphincter Electromyography Measures in Women with Stress Urinary Incontinence The primary objective of this study is to assess the effects of duloxetine 40 mg twice daily (BID) in women with urodynamically proved stress urinary incontinence (SUI) on the within-group change in v...

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An Extension Study to Evaluate the Long-Term Safety and Efficacy of the Phosphodiesterase Type 5 (PDE5) Inhibitor Tadalafil in the Treatment of Patients with Pulmonary Arterial Hypertension This study has 2 parts: (a) a blinded 52 week phase (Part 1), and (b) an open label phase (Part 2). The primary objective of Part 1 is to evaluate the long term safety of tadalafil 20 mg and 40 mg on...

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