A clinical study of oral ceritinib in patients with ALK-Positive Non-Small Cell Lung Cancer metastatic to the brain and/or to leptomeninges The primary objective is to evaluate the antitumor activity of Ceritinib in patients with ALK-positive NSCLC metastatic to the brain and/or to leptomeninges.

• Country None
• organs None
• Specialty None

Étude CPIM447X2104C : étude de phase 1, en escalade de dose, évaluant la tolérance de l’association du ruxolitinib, un inhibiteur de JAK1/2,avec le PIM447, un inhibiteur de PIM ou le LEE011, un inhibiteur de CDK4/6, ou les deux, chez des patients ayant une myélofibrose. [essai clos aux inclusions] La myélofibrose est un cancer rare de la moelle osseuse caractérisé par un développement et un fonctionnement anormaux des cellules sanguines produites dans la moelle osseuse, qui donne lieu à la form...

• Country France
• organs Sang Hématologie - Autres
• Specialty Thérapies Ciblées

A study of GSK1120212 compared with chemotherapy in patients with BRAF mutation positive advanced or metastatic melanoma The primary objective for this study is to establish the superiority of GSK1120212 over chemotherapy with respect to progression-free survival for subjects with advanced/metastatic BRAF V600E mutation...

• Country None
• organs None
• Specialty None

A Phase IV, Single-Centre, Observer-Blind, Controlled, Randomized Study to Compare the Safety and Immunogenicity of Fluvirin® to Influvac® Administered to Healthy Children 3 to 12 Years of Age To evaluate the immunogenicity of one 0.5mL and two 0.5mL intramuscular (IM) injections of FLUVIRIN® and Agrippal® administered 4 weeks apart

• Country None
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• Specialty None

Study of safety and efficacy of INC280 alone, and in combination with erlotinib, compared to chemotherapy, in advanced/metastatic non-small cell lung cancer patients with EGFR mutation and cMET amplification Phase Ib: To determine MTD and/or RP2D of INC280 in combination with erlotinib Phase II: To compare the antitumor activity of INC280 alone, and INC280 in combination with erlotinib, vs platinum with ...

• Country None
• organs None
• Specialty None

Study of efficacy and safety of INC424 in regularly transfused patients with thalassemia To assess the effect of INC424 on transfusion requirement

• Country None
• organs None
• Specialty None

Estudio abierto, de un único grupo, para evaluar la seguridad e inmunogenicidad de omalizumab líquido administrado por vía subcutánea en una jeringa de seguridad pre-cargada (75 mg o 150 mg) durante un periodo de 6 meses a hombres y mujeres adolescentes y adultos con asma alérgica persistente de moderada a grave Evaluar el potencial inmunogénico de omalizumab líquido cuando se administra durante un periodo de 6 meses en pacientes no expuestos a omalizumab, con asma alérgica persistente moderada a grave de 12 ...

• Country None
• organs None
• Specialty None

A Study to Test Trametinib and dabrafenib in Children and Adolescents Subjects with Cancer To determine the safe and tolerable trametinib dose(s) for chronic continuous daily dosing in pediatric subjects (infants, children, and adolescents) that achieves similar exposures (trough concentrat...

• Country None
• organs None
• Specialty None

Phase III study investigating the efficacy and safety of ruxolitinib in Early Myelofibrosis patients with high molecular risk mutations To evaluate the effect of ruxolitinib in delaying progression of MF from early disease to more advanced disease stages.

• Country None
• organs None
• Specialty None

Phase Ib/II study of certinib in combination with LEE011 in patients with ALK-positive Non-Small Cell Lung Cancer Estudio de seguridad y eficacia de LEE011 y ceritinib en pacientes con cáncer de pulmón de células no pequeñas ALK-positivo ?Phase Ib: To estimate the MTD(s) and/or RP2D(s) of LEE011 in combination with ceritinib in ALK-positive NSCLC patients as measured by the incidence of DLTs in Cycle 1 and by exposure to LEE011 and ce...

• Country None
• organs None
• Specialty None