This study will test an experimental drug called GS-9883/emtricitabine/tenofovir alafenamide (GS-9883/F/TAF) for the treatment of HIV-1 infection The purpose of this study is to test the effectiveness of switching to GS-9883/F/TAF versus continuing on a regimen containing boosted atazanavir (ATV) or darunavir (DRV) plus either emtricitabine/tenofovir (FTC/TDF) or abacavir/lamivudine (ABC/3TC) in virologically suppressed HIV-1 infected adult subjects (HIV-1 RNA < 50 copies/mL) To evaluate the efficacy of switching to a FDC of GS-9883/F/TAF versus continuing on a regimen consisting of boosted atazanavir or darunavir plus either FTC/TDF or ABC/3TC in HIV-1 infected adult subj...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A study with Ledipasvir/Sofosbuvir for adolecents and children with chronic Hepatitis C infection The primary objective of the PK Lead-in Phase of this study is: - To evaluate the steady state pharmacokinetics (PK) and confirm the dose of LDV/SOF FDC in chronic HCV-infected pediatric subjects The...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A study evaluating the safety and efficacy of the combination of GS-4059 and Entospletinib with and without obinutuzumab in subjects with chronic lymphocytic leukemia To determine the preliminary efficacy of finite therapy with the combination of GS-4059 and entospletinib with and without obinutuzumab in subjects with relapsed or refractory chronic lymphocytic leuk...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A Phase 2b, Double blind, Randomized, Parallel Group, Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of GS 9450 in Adults with Chronic Hepatitis C Virus Infection To compare the efficacy of two oral doses of GS 9450 to placebo in subjects with chronic HCV infection as evidenced by histologic response (at least a 2-point decrease in Knodell necroinflammatory sco...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

The purpose of this study is to test the effectiveness and safety of GS-6624 at different dose levels when it is given with Gemcitabine. We want to find out what effects, good and/or bad, GS-6624 has on you and your metastatic pancreatic adenocarcinoma when it is given with Gemcitabine. Gemcitabine is approved by the FDA for metastatic pancreatic adenocarcinoma To compare the additive efficacy of GS-6624 vs. placebo in combination with gemcitabine as measured by improvement in progression free survival (PFS)

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A trial investigating the safety and efficacy of a drug combination Sofosbuvir/Velpatasvir/GS-9857 for subjects with hepatitis C To determine the efficacy of treatment with sofosbuvir (SOF)/velpatasvir (VEL)/GS-9857 fixed dose combination (FDC) for 12 weeks as measured by the proportion of subjects with sustained viral response...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A Study to Assess a New Treatment in Patients with Moderately to Severely Active Crohn’s Disease The primary objectives of Cohort A Induction Study are: • To evaluate the efficacy of filgotinib as compared to placebo in establishing clinical remission by Patient Reported Outcomes (PRO2) at Week ...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

This trial will test the drug filgotinib for the treatment of fistulas around the anus (perianal) as a complication of Crohn’s disease. Este ensayo probará el fármaco filgotinib para el tratamiento de fístulas alrededor del ano (perianal) como una complicación de la enfermedad de Crohn The primary objective of this study is to evaluate the efficacy of filgotinib as compared to placebo in establishing combined fistula response at Week 24 Evaluar la eficacia de filgotinib en com...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A Clinical trial to evaluate safety, and effectiveness of GS-4997 in combination with an existing therapy (prednisolone) vs prednisolone alone in subjects with Severe Alcoholic Hepatitis The primary objective of this study is as follows: To evaluate the safety and tolerability of GS-4997 in combination with prednisolone versus prednisolone alone in subjects with severe AH.

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A Clinical Trial to Evaluate the Effects of the drug Aztreonam Lysine for Inhalation in Patients with Cystic Fibrosis, Mild Lung Disease, and infection with the bacteria Pseudomonas aeruginosa (AIR-CF4) The primary objective of this study is to assess the safety and efficacy of a 28-day course of AZLI in patients with CF, mild lung disease (FEV1 > 75% predicted), and PA.

• Pays Aucun
• Organes Aucun
• Spécialités Aucune