An 18-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of donepezil HCl (E2020) in patients with CADASIL who have cognitive impairment The primary objective of this study is to determine whether donepezil HCl confers cognitive benefit in patients with CADASIL who have cognitive impairment.

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

An early phase trial studying how well E7080 works in treating patients with advanced kidney cancer which has spread to other parts of the body. The first part of the trial will study the combination of E7080 and everolimus. The second part will compare the treatments when given alone and when given in combination. The trial is taking place worldwide, patients know if they are receiving the study drug alone, in combination with everolimus or if they are recieving everolimus alone Phase Ib: To determine the dose limiting toxicities and maximally tolerated dose and establish the recommended phase 2 (RP2) dose for E7080 incombination with everolimus in subjects with unresectable ...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

An open label dose adjustment and phase II study of E7070 in combination with capecitabine: Part 1: to determine the recommended dose of the combination Part 2: to determine the efficacy of the combination in patients with metastatic colorectal cancer (CRC) who are resistant to or unsuitable for treatment with 5-fluorouracil and irinotecan and/or oxaliplatin To determine the safety, tolerability and efficacy (in terms of response rate and progression-free survival) of the combination in patients with metastatic CRC resistant to or unsuitable for treatment...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A Phase 1b/2 trial studying how well lenvatinib works in treating children and adolescents with different types of cancer that are not responding to treatment or have reappeared following an initial recovery Cohort 1 (Single-Agent Dose-Finding)  Identify the recommended dose (RD) of lenvatinib as a single agent in children and adolescents with relapsed or refractory solid malignant tumors Cohort 2 (Sin...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A Randomized, Double-blind, Phase 2 Trial to assess how safe and how efficacious Lenvatinib is at two different starting doses (18 mg vs. 14 mg QD) when it is given in Combination with Everolimus (5 mg once a day ) in patients with Renal cancer that have already had one VEGF-Targeted Treatment Ensayo de fase 2, aleatorizado y doble ciego para evaluar la seguridad y la eficacia de lenvatinib en dos dosis iniciales diferentes (18 mg y 14 mg una vez al día) cuando se administra en combinación con everolimus (5 mg una vez al día) en pacientes con cáncer renal después de un tratamiento previo dirigido contra el VEGF To assess whether a starting dose of lenvatinib 14 mg in combination with everolimus 5 mg once daily (QD) will provide comparable efficacy (based on objective response rate [ORR]at 24 weeks[ORR24W]) w...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

Lemborexant for the treatment of insomnia disorder in older individuals LEMBOREXANTA PARA EL TRATAMIENTO DE INSOMNIO EN ADULTOS MAYORES Demonstrate using polysomnography (PSG) that 10 mg lemborexant (LEM10) is superior to zolpidem tartrate ER 6.25 mg (Ambien CR; ZOL) on objective sleep maintenance as assessed by wake after sleep onset...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

Double-Blind, Parallel-Group Comparison of 23 mg Donepezil Sustained Release to 10 mg Donepezil Immediate Release in Patients with Moderate to Severe Alzheimer’s Disease The primary objective of this study is to compare 23 mg donepezil SR with 10 mg donepezil IR in the treatment of patients with moderate to severe Alzheimer’s disease.

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

An open-label extension study following a double-blind, randomised, placebo-controlled, multi-centre study to assess the efficacy and safety of adjunctive zonisamide in paediatric partial onset seizures To assess the long-term safety of zonisamide used as an adjunctive treatment in paediatric subjects treated with one or two other anti-epileptic drugs (AEDs).

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A Clinical Trial comparing the Efficacy and Safety of Eribulin and a Treatment of the Doctor's Choice in Patients with Non-Small Cell Lung Cancer. ENSAYO CLÍNICO QUE COMPARA LA EFICACIA Y LA SEGURIDAD DE ERIBULINA Y UN TRATAMIENTO ELEGIDO POR EL MÉDICO EN PACIENTES CON CÁNCER DE PULMÓN NO MICROCÍTICO To compare overall survival (OS) in subjects with advanced non-small cell lung cancer (NSCLC) when treated with eribulin (Arm A) and treatment of physician?s choice ([TPC] Arm B). Comparar la su...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune

A Clinical Trial Comparing the Effectiveness and Safety of Eribulin and Dacarbazine for Treatment of Patients with Soft Tissue Sarcoma (A Type of Cancer)" "Un ensayo clínico que compara la eficacia y la seguridad de eribulina y dacarbazina en el tratamiento de pacientes con sarcoma de tejidos blandos (un tipo de cáncer) To compare overall survival (OS) in subjects with advanced soft tissue sarcoma ([STS], one of two subtypes: adipocytic [ADI] or leiomyosarcoma [LMS]) when treated with eribulin (Arm A) or dacarbazine ...

• Pays Aucun
• Organes Aucun
• Spécialités Aucune