ANDREA-LD; Anti-psychotic drug reduction in primary care for adults with Learning disabilities The principle objective is to evaluate the impact of a 6-month anti-psychotic medication withdrawal programme where neither the precribing GP nor the patient know which group they are in - the medicat...

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Determination of method-specific normal cortisol and adrenal hormone responses to the short Synacthen test To define the cortisol response to Synacthen in normal volunteers using commercially available cortisol immunoassays in use in clinical laboratories in the UK

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Controlled Antenatal Thyroid Screening study Background and study aims. There is evidence from previous studies that low thyroid function during pregnancy may affect the intelligence quotient (IQ) of the child. However there have been no prospe...

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A trial of directed therapy in younger patients with acute myeloid leukaemia: MRC AML 15 http://cancerhelp.cancerresearchuk.org/trials/a-trial-comparing-different-chemotherapy-regimes-and-the-use-of-mylotarg-monoclonal-antibody-in-treatment-of-acute-myeloid-leukaemia

• Pays United Kingdom
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Feasibility of alcohol screening and treatment in dental settings Background and study aims The majority of dental healthcare professionals (dentists, dental nurses and dental hygienists) do not routinely intervene to reduce the alcohol use of patients with hazardou...

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The AML18 Trial is an intensive chemotherapy trial for patients over the age of 60 with AML and High Risk Myelodysplastic disease. This randomised 1600 patient trial will evaluate the effect of adding novel treatment combinations to standard chemotherapy This trial will aim to answer the following questions: 1)Does a fractionated schedule of two doses of Mylotarg improve upon the current standard of 3mg/m2 on day 1 of course 1? 2)Does the addition o...

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The effect of different cardiovascular risk presentation formats on individuals’ intentions, understanding and emotional affect Not provided at time of registration

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A clinical trial to test the safety and effectiveness of a new drug, tefinostat, for patients with chronic myelomonocytic leukaemia 1. Is tefinostat (CHR-2845) safe and tolerable for patients with CMML? 2. Is tefinostat clinically effective in CMML? (primary efficacy endpoint will be overall clinical response rate according to t...

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Oral steroids for otitis media with effusion in children study (OSTRICH) To determine the clinical and cost effectiveness of a 7 day course of oral prednisolone (steroid) on improving hearing in the short term in children with bilateral OME with confirmed hearing loss for ...

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Bipolar Interactive PsychoEDucation trial Not provided at time of registration

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