A Single-Arm, Open-Label Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Adults with Chronic Hepatitis C Virus Genotype 4, 5, or 6 Infection To assess the efficacy (SVR12) and safety of 12 weeks of treatment with the ABT-493/ABT-530 combination regimen in adults with chronic HCV genotype (GT) 4, 5, or 6 infection without cirrhosis.

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A PHASE II, OPEN-LABEL STUDY EVALUATING THE SAFETY AND EFFICACY OF GDC-0199 (ABT- 199) PLUS BENDAMUSTINE PLUS RITUXIMAB (BR) IN COMPARISON WITH BR ALONE OR GDC-0199 PLUS RITUXIMAB (R) IN PATIENTS WITH RELAPSED AND REFRACTORY FOLLICULAR NON-HODGKIN’S LYMPHOMA To evaluate the efficacy of GDC-0199 plus Bendamustine and Rituximab (BR) compared with BR alone in patients with R/R FL. To evaluate the efficacy of GDC-0199 plus rituximab in patients with Relaps...

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A Study Evaluating Venetoclax in Combination with Azacitidine Compared with Azacitidine Alone in Subjects with Previously Untreated Higher-Risk Myelodysplastic Syndromes (MDS) The primary objectives of the study are to: • Assess the safety profile and pharmacokinetics (PK) of venetoclax in combination with azacitidine • Determine the recommended dose (RD) and dosing sche...

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An Open-Label, Multicenter Study to Evaluate Long-Term Outcomes with ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection The primary objective of this study is to evaluate the effect of response to treatment (assessed by SVR12 status) on the long-term progression of liver disease in adults with chronic HCV GT1 infection...

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A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/r With or without Dasabuvir and with Ribavirin in Chronic Hepatitis C Virus Genotype 1 or 4 Infected Adults with Successfully Treated Early Stage Hepatocellular Carcinoma Estudio para evaluar la seguridad y eficacia de Ombitasvir/Paritaprevir/r con o sin Dasabuvir y con Ribavirina en adultos con infección crónica por el virus de la hepatitis C de genotipo 1 o 4, y tratados con respuesta de un Carcinoma Hepatocelular en estadio inicial The primary objectives of this study are to assess the safety and efficacy the percentage of subjects achieving a 12-week sustained virologic response ([SVR12] [HCV ribonucleic acid {RNA} < lower limi...

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A study of subjects with rheumatoid arthritis who are in clinical remission to investigate patient and disease characteristics that could help identify which subjects could reduce their adalimumab dose without flaring The primary objective is to investigate the association between residual disease activity at Baseline as detected by magnetic resonance imaging (MRI) and the occurrence of flares in RA subjects rand...

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A Phase 2, Multicenter, Open-Label Extension (OLE) Study to Observe the Long-Term Efficacy, Safety, and Tolerability of Repeated Administration of ABT 494 in Subjects with Crohn's Disease To observe the long-term efficacy, safety, and tolerability of repeated administration of ABT-494 in subjects with Crohn's disease (CD) who completed Study M13-740.

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A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with Ribavirin in Adults with Genotype 1 and Ombitasvir/Paritabprevir/Ritonavir with Ribavirin in Adults with Genotype 4 Chronic Hepatitis C Virus Infection and Decompensated Cirrhosis The primary objectives of this study are to assess the safety and the percentage of subjects achieving a 12-week sustained virologic response, SVR12 [Hepatitis C Virus (HCV) ribonucleic acid (RNA) < l...

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A double-blind, placebo-contolled study to evaluate the safety and effect of three experimental drugs ABT-450, ABT-267, and ABT-333 with or without a drug called ribavirin in people with hepatitis C virus (HCV) that have not been treated before. "Experimental" means that they have not been approved by any regulatory agency for sale to the public The primary objectives of this study are to compare the safety of the combination of ABT-450/r/ABT-267 and ABT-333 administered with and without RBV for 12 weeks of treatment with ABT-450/r/ABT-267 an...

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A Randomized, Placebo Controlled Study of ABT-414 combined with Radiation and Temozolomide in Subjects with Newly Diagnosed Glioblastoma with Specific Tumor Markers Phase 2: to determine whether the addition of ABT-414 to concomitant radiotherapy and temozolomide prolongs progression free survival (PFS) in subjects with newly diagnosed GBM harboring EGFR amplifi...

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