A double-blind, placebo controlled study to assess the effects of early intervention and/or treatment with epoetin alfa on anaemia in cancer patients receiving non-platinum containing chemotherapy Not provided at time of registration

• Country None
• organs None
• Specialty None

A Phase I, open label, randomized, crossover trial in healthy subjects to investigate the effect of steady-state TMC278 on the pharmacokinetics of a single dose of digoxin To investigate the effect of steady-state TMC278 on the single dose PK of digoxin.

• Country None
• organs None
• Specialty None

SELENE : Essai de phase 3 randomisé, en double aveugle, évaluant l’efficacité et la tolérance de l’ibrutinib associé à une chimiothérapie associant le rituximab, le cyclophosphamide, la doxorubicine, la vincristine et la prednisone (R-CHOP) ou une chimiothérapie associant la bendamustine et le rituximab (BR), chez des patients ayant un lymphome non hodgkinien indolent à cellules B. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] L’objectif de cet essai est d’évaluer l’efficacité et la tolérance de l’ibrutinib en association avec une chimiothérapie, chez des patients ayant un lymphome non hodgkinien indolent à cellules B. Les...

• Country France
• organs Lymphomes non hodgkinien
• Specialty Chimiothérapie, Thérapies Ciblées

A study to determine effective and tolerable titration scheme for OROS-Methylphenidate in Children with Attention-deficit hyperactivity disorder The purpose of the study is to investigate the clinical benefit of switching children with ADHD from immediate-release methylphenidate (IR-MPH) to OROS-methylphenidate under the correct dosage convers...

• Country None
• organs None
• Specialty None

Study to evaluate optimized retreatment and prolonged therapy with bortezomib The objective of this study is to describe the effect of optimized retreatment with bortezomib in combination with dexamethasone followed by prolonged therapy with bortezomib, versus standard retreatm...

• Country None
• organs None
• Specialty None

An open-label study of two single oral doses of galantamine, examining the pharmacokinetics, safety, and tolerability in children with Down syndrome To determine the pharmacokinetic characteristics of glantamine after 2 single oral doses in children with Down syndrome.

• Country None
• organs None
• Specialty None

An Open-Label Evaluation of Safety of the IONSYS™ System [Fentanyl Iontophoretic Transdermal System (40 µg)] for Management of Acute Post- Operative Pain in Pediatric Patients The main objective of the study is to evaluate the safety of the IONSYS system for the management of postoperative pain in paediatric patients

• Country None
• organs None
• Specialty None

Randomised, double-blind, placebo-controlled, parallel-group trial to investigate the analgesic effect of OROS hydromorphone hydrochloride in comparison with placebo in subjects with moderate to severe pain induced by osteoarthritis of the hip or the knee To compare the analgesic effect of OROS hydromorphone hydrochloride with placebo in subjects with moderate to severe pain induced by osteoarthritis (OA) of the hip or knee which has not been adequatel...

• Country None
• organs None
• Specialty None

A Study of Guselkumab in Participants With Moderate to Severe Plaque-type Psoriasis and an Inadequate Response to Ustekinumab • To compare the efficacy of the following 2 treatment paradigms in subjects who have achieved an inadequate (Investigator’s Global Assessment [IGA] ≥2) response to ustekinumab at Week 16: - Switchi...

• Country None
• organs None
• Specialty None

An Open-label, Randomized Study of Subcutaneous and Intravenous VELCADE® in Subjects With Previously Treated Multiple Myeloma The primary objective is to compare the overall response rate ORR (CR+PR), after 4 cycles, of subcutaneously (SC) administered VELCADE® and intravenously (IV) administered VELCADE® in patients with pr...

• Country None
• organs None
• Specialty None