Second Course of Therapy for Resistant Patent Ductus Arteriosus (PDA) Patency of the ductus arteriosus (PDA) is functionally essential for fetal circulation, however persistence of ductal patency postnatally may have significant adverse hemodynamic effects i...

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Pentoxifylline in the Treatment of NEC in Premature Neonates Pentoxifylline improves microcirculation and decreases TNF alpha levels associated with sepsis, rendering it of potential therapeutic value in necrotizing enterocolitis in premature neonat...

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Treating the Resistant Patent Ductus Arteriosus (PDA) Persistent postnatal ductal patency may have significant adverse hemodynamic effects, frequently necessitating therapeutic intervention in order to facilitate ductal closure. Medical thera...

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Ibuprofen vs. Continuous Indomethacin in the Treatment of PDA The purpose of this study is to determine whether closure of the PDA in premature neonates using IV ibuprofen vs continuous IV indomethacin has different side effects, eg. effects on renal...

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Paracetamol Treatment of the Borderline Significant PDA The therapeutic approach to the patent ductus arteriosus (PDA) in the premature neonate remains controversial. Currently it is generally accepted to treat only hemodynamically significant ...

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Heat Killed Probiotics in the Prevention of Necrotizing Enterocolitis Prophylactic probiotics have been shown to decrease the incidence of Necrotizing Enterocolitis (NEC) in premature neonates. However, there is some resistance to giving live bacteria to sma...

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Paracetamol and Patent Ductus Arteriosus (PDA) The investigators propose that paracetamol will be similarly effective to ibuprofen in treating PDA in the premature neonate, with fewer side effects.

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Prebiotics in the Prevention of Necrotizing Enterocolitis Necrotizing enterocolitis (NEC) is the most common gastrointestinal catastrophe affecting 10-15% of premature neonates of <1500 gm. NEC is a disease of the immature intestine, characterize...

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