Abiraterone with Different Steroid Medications Regimens for side effect prevention in [metastatic castrate-resistant] prostate cancer patients prior to chemotherapy treatment To evaluate the safety of abiraterone acetate with 4 alternative steroid treatment strategies related to symptoms associated with mineralocorticoid excess toxicities (ie, hypokalemia and/or hypertensi...

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A Randomized Study to Evaluate the Effectiveness, Safety, and Tolerability of Canagliflozin in Subjects With Type 2 Diabetes Mellitus With Inadequate Glucose Control and on Metformin Monotherapy After 18 weeks of treatment: -To assess the effect of canagliflozin 150 mg administered twice daily on HbA1c relative to placebo - To assess the safety and tolerability of canagliflozin

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A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Dose Ranging Study to Investigate the Safety and Efficacy of JNJ-16269110 in Overweight and Obese Subjects The primary objective of the study is to find the appropriate, clinically relevant dosages (among the 5, 10, and 15 mg twice-daily dosages) of JNJ-16269110 by assessing mean changes in body weight fro...

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A Prospective Randomized Open-label 6-Month Head-To-Head Trial to Evaluate the Safety and Tolerability of Paliperidone ER and Olanzapine in Subjects with Schizophrenia The primary objective is to show that paliperidone is superior to olanzapine in the improvement of the triglyceride to high density lipoprotein ratio (TG:HDL ratio)

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A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of Carisbamate as Adjunctive Therapy in Subjects With Partial Onset Seizures, Followed by an Open-Label Extension Study The primary objective of this study is: · To obtain long-term safety and tolerability data on subjects with partial onset seizures treated with open-label carisbamate

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A Double-Blind, Randomized, Placebo-Controlled, Parallel Group Exploratory Study of the Safety and Efficacy of JNJ-39758979 in the Treatment of Adults with Persistent Asthma •To evaluate the safety and efficacy (in terms of improvement in pre-bronchodilator FEV1) of once daily oral administration of JNJ-39758979 in the treatment of adults with persistent asthma as defined...

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A Randomized, Double-blind, Placebo-controlled Trial of Long-term (2-year) Treatment of Galantamine in Mild to Moderately-severe Alzheimer’s Disease Overall objective The overall objective of this study is to evaluate the benefit-risk of long-term (over the course of 2 years) treatment with galantamine as compared with placebo in subjects with mil...

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A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating Epoetin Alfa Initiated at 40,000 IU Every Week or 80,000 IU Every Week Versus Placebo in Subjects With IPSS Low- or Intermediate-1 Risk Myelodysplastic Syndromes at Risk for Transfusion The primary objective is to demonstrate that epoetin alfa treatment reduces the proportion of anemic subjects with International Prognostic Scoring Systems (IPSS) Low or Intermediate 1 risk myelodysp...

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A Study of TMC435 plus Pegylated Interferon alfa-2a and Ribavirin in Participants with Chronic HCV Infection - To determine the efficacy of TMC435 plus PegIFNalfa-2a and RBV when administered for 12 weeks in treatment-naïve subjects with chronic genotype 1 HCV infection, as measured by the proportion of subj...

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A Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of JNJ-37822681 Administered Twice Daily in Subjects With Schizophrenia Primary Objective The primary objective is to evaluate the efficacy via the changes from baseline in the total Positive and Negative Syndrome Scale (PANSS) score of three fixed doses of JNJ-37822681 c...

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