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Kusajili – Centralise les essais cliniques mondiaux
Résultat
de votre recherche par promoteur : Merck Serono International
Femme et Homme Max 99 ans
Merck Serono International SA
MAJ Il y a 5 ans
Estudio en fase IIIb, multicéntrico, comparado con grupo de control, doble ciego, aleatorizado y de dos brazos, con evaluaciones mensuales por resonancia magnética y biomarcadores para evaluar la eficacia, la seguridad y la tolerabilidad de Rebif New Formulation (IFN beta-1a) en pacientes con esclerosis múltiple remitente-recurrente. A two-arm, randomized, double-blind, control group-compared, multicenter, phase IIIb study with monthly MRI and biomarker assessments to evaluate the efficacy, safety, and tolerability of Rebif® New Formulation (IFN-beta-1a) in subjects with relapsing remitting multiple sclerosis
To evaluate the efficacy of Rebif® New Formulation (RNF), compared to placebo, in subjects with Relapsing Remitting Multiple Sclerosis and active disease by means of Magnetic Resonance Imaging (MRI) a...
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unknown
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Femme et Homme Max 99 ans
Merck Serono International
MAJ Il y a 5 ans
A randomised, double-blind, placebo controlled, multi-centre phase II study of atacicept in anti- TNF alfa-naïve patients with moderate to severely active rheumatoid arthritis and an inadequate response to methotrexate
The primary objective of this study is to evaluate the efficacy of atacicept compared to placebo in the treatment of signs and symptoms in a subject population with active RA, inadequate response to m...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Merck Serono International S.A
MAJ Il y a 5 ans
A phase III, double-blind, placebo-controlled, randomised trial to determine the efficacy and safety of a dose range of 50 to 100 mg/day of safinamide, as add-on therapy, in subjects with idiopathic Parkinson’s Disease with motor fluctuations, treated with a stable dose of levodopa and who may be receiving concomitant treatment with stable doses of a dopamine agonist, an anticholinergic and/or amantadine
The objectives of this trial are to evaluate the efficacy and safety of a dose range of safinamide 50-100 mg p.o. q.a.m., compared to placebo as add-on therapy in subjects with idiopathic Parkinson’s ...
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unknown
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Femme et Homme Max 99 ans
Merck Serono International SA
MAJ Il y a 5 ans
A phase II, multicenter, randomized, double-blind, placebo-controlled, safety, tolerability and efficacy study of add-on Cladribine tablet therapy with Rebif New Formulation in Multiple Scleroris Subjects with Active Disease
Evaluate the safety and tolerability of oral cladribine (cladribine tablets)when added on to Rebif. Evaluate the efficacy of oral cladribine (cladribine tablets) when added on to Rebif compared to pla...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Merck Serono International
MAJ Il y a 5 ans
A randomised, double-blind, placebo controlled, multi-centre, exploratory, pilot, phase II trial of 150 mg atacicept given subcutaneously in combination with rituximab in subjects with rheumatoid arthritis
The primary objective is to assess the safety and tolerability of combined treatment with atacicept and rituximab in subjects with active rheumatoid arthritis receiving re-treatment with rituximab.
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Essai clos aux inclusions
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Femme Max 99 ans
Merck Serono International S.A
MAJ Il y a 5 ans
A phase II, multicentre, randomised, assessor.blinded, active-comparator, parallel-group dose finding trial to evaluate AS900672-Enriched versus follitropin alfa (GONAL-f) in oligo-anovulatory infertile women undergoing ovulation induction (OI)
The primary objective: Identify the optimal dose of AS900672- Enriched to induce ovulation in oligo-anovulatory infertile women.
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Essai clos aux inclusions
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Femme Max 99 ans
Merck Serono International, A branch of Laboratoires Serono S.A
MAJ Il y a 5 ans
A multinational, multicenter, exploratory pharmacogenomics trial to test the importance of identified genetic markers, and potentially identify new markers of various ovarian responses to GONAL-f® treatment in women undergoing assisted reproduction technology (ART)
To assess the relative importance of genetic markers identified in the literature predictive of ovarian response to GONAL f®.
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Merck Serono International
MAJ Il y a 5 ans
A Phase 2/3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Atacicept in Subjects with Lupus Nephritis in Combination with Mycophenolate Mofetil Therapy
The primary objective is to evaluate the efficacy of atacicept compared to placebo in subjects with active LN receiving immunosuppressive therapy with MMF (mycophenolate mofetil).
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Merck Serono International
MAJ Il y a 5 ans
An open-label, multicenter phase II extension of study 28063 (ATAMS) to obtain long-term follow-up data in patients with relapsing multiple sclerosis treated with atacicept for up to 5 years (ATAMS-Extension)
The main objective of the study is to monitor the long-term safety and tolerability of atacicept administered for up to 5 years to subjects with relapsing multiple sclerosis (RMS).
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Merck Serono International, An affiliate of Merck KGaA, Darmstadt, Germany
MAJ Il y a 5 ans
A Phase II/III, randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of atacicept in combination with corticosteroids and sequential therapy with cyclophosphamide and azathioprine in subjects with lupus nephritis
PRIMARY The primary objective of this trial is to evaluate the efficacy of atacicept compared to placebo in subjects with active LN who are receiving corticosteroids and sequential therapy with cyclop...
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Essai clos aux inclusions
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