A twenty six-week, randomized, double-blind, parallel group, multicenter, active controlled, dose titration study to evaluate the efficacy and safety of aliskiren compared to HCTZ with the optional addition of amlodipine, followed by a second twenty six weeks of blinded treatment in patients with essential hypertension Compare the long term efficacy of an aliskiren based treatment regimen (aliskiren 150 mg, 300 mg with optional add-on of amlodipine 5 mg/10 mg) to a HCTZ based treatment regimen (HCTZ 12.5 mg, 25 mg ...

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Study to assess the effect of bimagrumab withdrawal in older adults with sarcopenia (low muscle mass and mobility). Estudio para evaluar el efecto de la retirada de bimagrumab en adultos de edad avanzada con sarcopenia (baja masa y mobilidad muscular) Assess the durability of effect of bimagrumab (BYM) by comparing withdrawal of BYM (i.e., BYM/placebo PBO switch) treatment with continued BYM administration every 4 weeks for 24 additional weeks of t...

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Estudio multicéntrico, de fase II, aleatorizado, doble ciego, controlado con placebo, de 12 semanas de duración, para evaluar la respuesta al tratamiento (ACR20) y para determinar un perfil de biomarcadores en pacientes adultos con artritis reumatoide establecida respondedores a ACZ885 (anticuerpo monoclonal anti-interleuquina-1β) comparado con sujetos sanos expuestos a ACZ885 • Evaluar la respuesta al tratamiento (ACR20) en pacientes adultos con artritis reumatoide establecida (AR) después de 6 y 12 semanas de tratamiento con ACZ885. • Identificar un perfil de biomarcadore...

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Dose range finding study in sarcopenia Estudio en sarcopenia de búsqueda de dosis Assess the effect of bimagrumab on the 6 minute walk test (6MWT) as assessed by change from baseline to week 25 relative to placebo. Evaluar el efecto de bimagrumab mediante la prueba de marcha...

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