A Randomized, Double-blind, Active-controlled Study to Evaluate the Efficacy and Safety of Denosumab Compared With Risedronate in Glucocorticoid-treated Individuals The primary objective in the glucocorticoid-continuing subpopulation of men and women treated with chronic glucocorticoid therapy is to demonstrate that treatment with denosumab 60 mg subcutaneously...

• Country None
• organs None
• Specialty None

A Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Palifermin (Recombinant Human Keratinocyte Growth Factor) for Reduction of Oral Mucositis in Subjects with Stage 2B or 3 Locally Advanced, Colon Cancer Receiving 5-FU and Leucovorin as Adjuvant Therapy To evaluate the effect of palifermin on the incidence of Grade ≥ 2 OM induced by adjuvant chemotherapy in subjects with stage 2B and 3 locally advanced colon cancer in cycle 1, when administered as a ...

• Country None
• organs None
• Specialty None

Étude 20160275 : étude de phase 3 randomisée visant à comparer l’efficacité de l’association carfilzomib, dexaméthasone et daratumumab avec celle de l’association carfilzomib et dexaméthasone chez des patients ayant un myélome multiple récurrent ou réfractaire. [essai clos aux inclusions] Le myélome multiple est une maladie maligne touchant les plasmocytes de la moelle osseuse, qui font partie des globules blancs assurant la défense contre les infections. Si un type malin de plasmocyte...

• Country France
• organs Myélomes
• Specialty Immunothérapie - Vaccinothérapie, Thérapies Ciblées

A Randomized Double-blind Placebo-controlled Study to Evaluate the Efficacy and Safety of Cinacalcet for the Treatment of Hypercalcemia in Subjects With Primary Hyperparathyroidism Unable to Undergo Parathyroidectomy to demonstrate the efficacy of cinacalcet for normalizing corrected total serum calcium in subjects with primary HPT who meet criteria for parathyroidectomy on the basis of corrected total serum calci...

• Country None
• organs None
• Specialty None

Study to Assess the Effect of Evolocumab on Ability to Learn Compared with Placebo in patients with Cardiovascular Disease who are already taking Statin Therapy To evaluate change over time in executive function, as assessed by the Cambridge Neuropsychological Test Automated Battery (CANTAB) Spatial Working Memory (SWM) strategy index of executive function, ...

• Country None
• organs None
• Specialty None

AMGEN 20080580 : Essai de phase 2 évaluant l’efficacité et la tolérance de l’AMG 386 associé à du sorafénib, en traitement de première ligne, chez des patients ayant un carcinome hépatocellulaire. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] Phase 2, open-label, single-arm, multi center study to evaluate the efficacy and safety of AMG 386 and sorafenib as first line therapy for subjects with advanced or inoperable hepatocellular carcinoma...

• Country France
• organs Primitif du foie
• Specialty Thérapies Ciblées, Chimiothérapie

An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with immune (Idiopathic) Thrombocytopenia Purpura (ITP).------------------------------------------------ Estudio Abierto para Evaluar la Seguridad y Eficacia del Tratamiento a Largo Plazo con Romiplostim en Sujetos Pediátricos Trombocitopénicos con Púrpura Trombocitopénica Inmune (Idiopática) (PTI) The primary objective of this study is to evaluate the safety of romiplostim as a long-term treatment in pediatric thrombocytopenic subjects with immune (idiopathic) thrombocytopenic purpura (ITP).

• Country None
• organs None
• Specialty None

A Phase 1b/2 Trial of AMG 655 in Combination with Panitumumab in Subjects with Metastatic Colorectal Cancer This study is divided into 2 parts: a phase 1b portion (part 1) and a phase 2 portion (part 2). Part 1: The primary objective of part 1 is to identify a tolerable dose of AMG 655 in combination with...

• Country None
• organs None
• Specialty None

A Randomized, Multicenter Phase 3 Study to Compare the Efficacy of Panitumumab in Combination with Chemotherapy to the Efficacy of Chemotherapy Alone in Patients with Previously Treated Metastatic Colorectal Cancer To evaluate the treatment effect of panitumumab plus FOLFIRI on overall survival (OS) and progression-free survival (PFS) compared to FOLFIRI alone as second line therapy for metastatic colorectal can...

• Country None
• organs None
• Specialty None

Amgen 20050190 : Essai de phase 2 randomisé évaluant un traitement par AMG 951 chez des patients ayant un cancer du poumon traité par chimiothérapie avec ou sans bévacizumab.. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] A multicenter, open label, randomized study of AMG 951 in subjects with previously untreated stage IIIb/IV non-small cell lung cancer (NSCLC) treated with chemotherapy with or without bevacizumab.

• Country France
• organs Poumon, type non à petites cellules
• Specialty Chimiothérapie, Thérapies Ciblées