A multicentre, double-blind, randomised, parallel-group study to evaluate the efficacy, safety and tolerability of ezetimibe/simvastatin 10/40mg, atorvastatin 40mg, and rosuvastatin 10mg to achieve an LDL-C level of <2mmol/l in patients with established CVD or at “high risk” of developing CVD, currently treated with simvastatin 40mg and with a fasting LDL-C 2 mmol/l To evaluate the percentage of patients with either established CVD, at “high risk” of developing CVD or with diabetes who are on simvastatin 40mg, with fasting LDL-C 2mmol/l, who are able to attain t...

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A Phase IIa Randomized, Double-Blind, Parallel-Group, Placebo and Active-Controlled, Clinical Trial to Study the Efficacy and Safety of MK-0974 Co-administered with Ibuprofen or Acetaminophen in Patients with Migraine With or Without Aura 1. To evaluate the efficacy of MK-0974 co-administered with ibuprofen or acetaminophen/paracetamol compared to MK-0974 alone in the treatment of acute migraine, as measured by pain freedom at 2 hours...

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A study in healthy, young adults and healthy infants of the safety, tolerability, and immunogenicity of an investigational manufacturing process for the recombinant hepatitis B vaccine (The study is designed in 2 stages) Stage 1: To assess the safety and tolerability of GSH/2X phosphate hepatitis B vaccine in healthy adults. Stage 2 (contingent upon meeting safety requirements of ...

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Safety and Efficacy of suvorexant (MK-4305) for the treatment of insomnia in AD subjects (1) To evaluate the efficacy of suvorexant compared with placebo in improving insomnia, as measured by change from baseline in PSG-derived total sleep time (TST), at Week 4. (2) To evaluate the safety...

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A Phase III Study of Pembrolizumab in Subjects with Gastric Cancer 1. To evaluate Progression Free Survival (PFS) per RECIST 1.1 by blinded central radiologists’ review of subjects with PD-L1 positive expression with advanced gastric or GEJ adenocarcinoma who have pr...

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Corifollitropin alfa trial in adult men with hypogonadotropic hypogonadism (HH) The primary objectives of the trial are: 1) to assess the efficacy of 150 µg MK-8962, given once every two weeks for 52 weeks - in combination with a twice weekly dose of hCG - to increase testicular ...

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A Multicenter, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of the Initial Therapy With Coadministration of Sitagliptin and Pioglitazone in Patients With Type 2 Diabetes Mellitus Objective: After 24 weeks, to assess the effect of the coadministration of sitagliptin 100 mg q.d. and pioglitazone 30 mg q.d. compared to pioglitazone alone on HbA1c. Objective: To assess the safet...

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Sitagliptin with atorvastatin in patients with type 2 diabetes mellitus who have inadequate glycemic control on metformin monotherapy. Szitagliptin és atorvasztatin olyan 2-es típusú diabetes mellitusban szenvedő betegekben vizsgálva, akiknél metformin monoterápia mellett a vércukorszint kontroll nem megfelelő Objective 1: To assess the effect of sitagliptin in combination with atorvastatin compared to atorvastatin alone on A1C after 16 weeks of treatment. Objective 2: To assess the effect of atorvastatin ...

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A Study Comparing MK-8808 to MabThera™ in Patients with Advanced Follicular Lymphoma. Studio di confronto MK-8808 Vs MabThera in Pazienti con linfoma follicolare avanzato To compare the CR+CRu rate of MK-8808 plus CHOP versus MabThera plus CHOP at week 20 (+/- 1 week) after randomization. Confrontare il tasso di risposte complete (CR) e risposte complete non con...

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A Phase III, Randomized, Clinical Trial to Evaluate the Safety and Efficacy of the Addition of Sitagliptin in Patients With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on a Sulfonylurea in Combination With Metformin 1) After 24 weeks, to assess the effect of the addition of treatment with sitagliptin on A1C compared with the addition of placebo; 2) To assess the safety and tolerability of the addition of sitagli...

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