Study of efficacy and safety of QAW039 in patients with severe asthma inadequately controlled with standard of care asthma treatment In patients with severe asthma and high eosinophil counts (≥250 cells/μl) receiving SoC asthma therapy, to demonstrate the efficacy (as measured by rate of moderate-to-severe asthma exacerbations) of ...

• Country None
• organs None
• Specialty None

Study of safety, tolerability and preliminary efficacy of multiple intra-articular LNA043 injections in patients with articular cartilage lesions • To assess the efficacy of multiple i.a. injections of LNA043 in regenerating the articular cartilage tissue • To assess safety and local tolerability of multiple i.a. injections of LNA043

• Country None
• organs None
• Specialty None

Étude CLXS196X2101 : étude de phase 1 non-randomisée visant à évaluer la sécurité d’emploi, la tolérance, la pharmacocinétique, la pharmacodynamique et l’efficacité du LXS196 en monothérapie et en association au HDM201 chez des patients ayant un mélanome uvéal métastatique. [essai clos aux inclusions] Le mélanome uvéal est le cancer de l’oeil le plus fréquent chez l’adulte, mais il reste une maladie rare. Dans 20 à 50% des cas, ce cancer forme des métastases, souvent dans le foie. La tumeur primair...

• Country France
• organs Mélanomes oculaires
• Specialty Thérapies Ciblées

Efficacy and Safety of Everolimus in Liver Transplant Recipients of Living Donor Liver Transplants To demonstrate comparable efficacy as measured by the composite efficacy failure of tBPAR, graft loss or death with EVR in combination with rTAC compared to standard exposure TAC, at 12 months post-tr...

• Country None
• organs None
• Specialty None

Everolimus as Second-line Therapy in Metastatic Renal Cell Carcinoma To assess the progression-free survival (PFS) in patients who receive everolimus as second-line treatment for metastatic renal cell carcinoma

• Country None
• organs None
• Specialty None

An exploratory study of the effects of Imatinib on allergic inflammation following out of allergy season repeated nasal allergen challenge in subjects with seasonal allergic rhinitis sensitive to Timothy grass pollen – an exploratory study of c-kit inhibition in allergic respiratory diseases To assess the effects of Imatinib on allergic inflammation following repeated nasal allergen challenge (NAC) in subjects with seasonal allergic rhinitis sensitive to Timothy grass pollen – in particul...

• Country None
• organs None
• Specialty None

A randomized, active-controlled, open-label, multicenter cross-over study with two 6-week treatment periods to investigate the effect of the combination of Lescol XL (fluvastatin) 80 mg and fenofibrate 200 mg on HDL-C in comparison to the combination of simvastatin 20 mg and ezetimibe 10 mg in patients with metabolic syndrome To confirm that the combination of fluvastatin 80 mg extended release (ER) and fenofibrate 200 mg has superior efficacy in increasing HDL-C compared with the combination of simvastatin 20 mg and ezeti...

• Country None
• organs None
• Specialty None

A double blind, placebo controlled, parallel group study with an open label reference arm to assess the effects of intravenously administered AIN457 on ozone induced neutrophilia compared to placebo and oral corticosteroid in healthy volunteers • To assess the ability of AIN457 to inhibit ozone-induced airway neutrophilia (total neutrophil cell count in 106/mL) in induced sputum at 24 hours compared to placebo

• Country None
• organs None
• Specialty None

CAUY922A2202 : Essai de phase 2 randomisé comparant l’efficacité de l’AUY922 à une chimiothérapie par docétaxel ou irinotécan, chez des patients ayant un cancer gastrique avancé. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] L’objectif de cet essai est de comparer l’efficacité de l’AUY922, à une chimiothérapie par docétaxel ou irinotécan, chez des patients ayant un cancer gastrique avancé. Les patients seront répartis de...

• Country France
• organs Estomac
• Specialty Chimiothérapie

Étude NATALEE : étude de phase 3, randomisée, évaluant l'efficacité et la tolérance du ribociclib associé à un traitement endocrine, comme traitement adjuvant, chez des patients ayant un cancer du sein HR+/HER2-. A phase III multi-center, randomized, open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as an adjuvant treatment in patients with hormone receptor-positive, HER2-ne...

• Country France
• organs Sein
• Specialty Thérapies Ciblées, Hormonothérapie