A placebo-controlled trial with rFXIII administered to subjects with mild to moderate active ulcerative colitis To assess the effects of rFXIII on mucosal healing

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A trial investigating efficacy and safety of insulin detemir versus insulin Neutral Protamine Hagedorn (NPH) in combination with metformin and diet/exercise on glycaemic control in children and adolescents with type 2 diabetes insufficiently controlled on metformin ± other oral antidiabetic drug(s) ± basal insulin To compare the efficacy of insulin detemir in combination with metformin and diet/exercise versus insulin Neutral Protamine Hagedorn (NPH) in combination with metformin and diet/exercise in controllin...

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Efficacy and Safety of Faster-acting Insulin Aspart compared to NovoRapid® both in Combination with Insulin Degludec in Children and Adolescents with Type 1 Diabetes To confirm the effect of treatment with meal-time faster-acting insulin aspart in terms of glycaemic control by comparing it to meal-time NovoRapid®, both in combination with insulin degludec using a ...

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Multiple dose trial examining dose range, escalation and efficacy of oral semaglutide in subjects with type 2 diabetes To compare the efficacy on glycaemic control of oral semaglutide in a SNAC formulation against placebo in subjects with T2D

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A 16 week randomised, open labelled, 3-armed, treat-to-target, parallel group trial comparing SIBA (D) once daily + NovoRapid®, SIBA (E) once daily + NovoRapid® and insulin glargine once daily + NovoRapid®, all in a basal/bolus regimen in subjects with type 1 diabetes To assess glucose control with respect to HbA1c after 16 weeks of treatment with SIBA (D) QD + NovoRapid® or SIBA (E) QD + NovoRapid® compared with that of insulin glargine QD + NovoRapid®, all in a b...

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An Open-label, Multi-centre, Un-controlled Trial to Assess Efficacy and Safety of NNC-0156-0000-0009 during Surgical Procedures in Patients with Haemophilia B To evaluate the haemostatic effect of NNC-0156-0000-0009 during surgery procedures in patients with haemophilia B

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LEADER Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results A Long-term, Multi-centre, International, Randomised Double-blind, Placebo-controlled Trial to Determine Liraglutide Effects on Cardiovascular Events To assess the effect of treatment with liraglutide compared to placebo for at least 3.5 year and up to 5 years on the incidence of cardiovascular events, as defined by the below primary and secondary ...

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A trial comparing efficacy and safety of NN1250 and insulin glargine in subjects with type 2 diabetes To confirm the efficacy of SIBA 200 U/ml once daily + metformin ± DPP-4 inhibitor in controlling glycaemia with respect to change from baseline in HbA_1c after 26 weeks of treatment. This is done by c...

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A trial investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of a single dose of long-acting growth hormone compared to daily dosing of Norditropin® SimpleXx® in children with growth hormone deficiency To evaluate safety and tolerability of a single subcutaneous (s.c.) dose of NNC0195-0092 compared to daily dosing of Norditropin® SimpleXx® for seven days in children with growth hormone deficiency (G...

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A Multi-Centre, Randomised, Double-Blind, Placebo Controlled Trial on Efficacy and Safety of FXIII Replenishment with two different Doses of Recombinant Factor XIII following Cardiopulmonary Bypass Surgery To investigate whether postoperative treatment with either of two doses (17.5 or 35 IU/kg LBM) of recombinant factor FXIII (rFXIII) is effective in avoiding any allogeneic transfusions in cardio pulmo...

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