A trial comparing the efficacy and safety of insulin degludec three times weekly in insulin naïve subjects with type 2 diabetes mellitus when titrated using two different titration algorithms To confirm the efficacy of the IDeg 200U/ml 3 times weekly (3TW) simple titration algorithm + metformin in controlling glycaemia with respect to change from baseline glycosylated haemaglobin (HbA1c) a...

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Effect of liraglutide on body weight in obese subjects without diabetes. A 20-week randomised, double-blind, placebo-controlled, six armed parallel group, multi-centre, multinational trial with an open label orlistat comparator arm with an 84 week extension period Trial Phase:2b To investigate the efficacy of liraglutide to induce weight loss

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A randomised, double-blind, placebo-controlled, parallel-group trial to assess clinical efficacy and safety of NNC0114-0006 in subjects with active Crohn’s disease To compare the effect on disease activity of a single i.v. dose of NNC0114-0006 with placebo in subjects with moderately to severely active Crohn’s disease

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A 32 week, national, single-centre, open-labelled, randomised, cross-over trial comparing energy expenditure with insulin detemir versus NPH insulin using a basal-bolus regimen with insulin aspart as mealtime insulin in subjects with type 1 diabetes To measure energy expenditure before and after 16 weeks of treatment with insulin detemir in combination with insulin aspart as mealtime insulin, in comparison with energy expenditure before and after...

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Multi-Centre, Open-Label, Randomised Trial Investigating the Pharmacokinetics of a Single Dose of NNC 0155-0000-0004 (N8) in Patients with Haemophilia A To evaluate the pharmacokinetics (PK) of two different lots of N8 after a single intravenous (i.v.) administration of 50 IU/kg b.w. in patients with haemophilia A.

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A 26 week randomised, open labelled, parallel group, multi-national, treat-to-target trial comparing efficacy and safety of insulin detemir once daily in combination with sitagliptin and metformin versus sitagliptin and metformin with or without sulphonylurea, in subjects with type 2 diabetes To compare glycaemic control, measured as HbA1c, of insulin detemir given once daily in combination with sitagliptin and metformin versus sitagliptin and metformin ± SU after a 26-week treatment perio...

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An extension trial to NN1250-3585 investigating safety and efficacy of NN1250 compared to insulin detemir in subjects with type 1 diabetes mellitus in a basal/bolus treatment regimen The primary objective is to investigate the long-term safety and tolerability of NN1250 in combination with insulin aspart. This is done by comparing NN1250 to insulin detemir, both in combination wit...

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Outcome Trial Evaluating the Efficacy and Safety of Norditropin® in Adult Patients on Chronic Haemodialysis A Randomised, Double-blind, Parallel group, placebo controlled, Multi-centre trial To evaluate and establish the effect of Norditropin® (somatropin) on mortality in adult patients on chronic haemodialysis

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A trial investigating the mechanism of action of NNC0109-0012 (anti-IL-20 mAb) through synovial biopsies in subjects with rheumatoid arthritis and an inadequate response to Methotrexate To explore the potential differences in the mechanism of action through analysis of synovial biopsies in subjects with active rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX)...

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A randomised, parallel-group, open-labelled, multinational trial comparing the efficacy and safety of insulin detemir (Levemir®) versus human insulin (NPH insulin), used in combination with insulin aspart as bolus insulin, in the treatment of pregnant women with type 1 diabetes Trial Phase: 3b To compare the glycaemic control measured as HbA1c obtained by using either insulin detemir or NPH insulin at gestational week (GW) = 36 (P4).

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