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Kusajili – Clinical trials directory
Result
of your search per sponsor: F. Hoffmann-La Roche Ltd
Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 5 ans
A randomized, double-blind, parallel-group study of the reduction of signs and symptoms during treatment with tocilizumab versus adalimumab, both in combination with MTX, in patients with moderate to severe active rheumatoid arthritis and an inadequate response to treatment with only one TNF inhibitor
To assess the efficacy of treatment with tocilizumab (TCZ) 8 mg/kg intravenously (iv) (every 4 weeks) versus adalimumab (ADA) 40 mg subcutaneously (sc) (every 2 weeks), both in combination with methot...
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organs
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Specialty
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Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 5 ans
An Open-Label Extension Study to assess the long-term safety and effective of etrolizumab treatment for patients with moderately to severely active Crohn's disease
The objectives of this open-label extension−safety monitoring (OLE-SM) study are as follows: Part 1 (Open-Label Extension; OLE) • To assess the long-term safety and efficacy of etrolizumab in patien...
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organs
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Specialty
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unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 5 ans
anti-TNF-IR phase III
To determine the efficacy and safety of ocrelizumab versus placebo in reducing signs and symptoms of rheumatoid arthritis (RA), when used in combination with methotrexate (MTX) or leflunomide given ...
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None
organs
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Specialty
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Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 5 ans
Open label, randomized, multicenter study to investigate the efficacy and safety of once-weekly (reduced administration frequency) NeoRecormon® (Epoetin beta) therapy versus thrice weekly NeoRecormon® therapy in anemic patients with metastatic solid tumors receiving chemotherapy (or scheduled to receive chemotherapy)
• To demonstrate that epoetin beta (NeoRecormon®) administered 30,000 IU once weekly (q1w) subcutaneously (sc) is at least as efficacious as epoetin beta (NeoRecormon®) administered 10,000 IU sc th...
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None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 5 ans
Ensayo randomizado, doble ciego, con doble enmascaramiento, de grupos paralelos para evaluar la eficacia y seguridad de RO4402257 como monoterapia en comparación con la monoterapia de metotrexato para pacientes con artritis reumatoide activa (AR) A randomized, double-blind, double-dummy, parallel group study to determine the efficacy and safety of RO4402257 monotherapy in comparison to methotrexate monotherapy in patients with active rheumatoid arthritis (RA)
Evaluar la eficacia de RO4402257 como monoterapia en pacientes adultos con AR activa.
Country
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organs
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Specialty
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unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 5 ans
An open-label, multicenter protocol providing pegylated interferon alfa-2a (PEGASYS) as monotherapy or in combination with ribavirin (COPEGUS) for patients with chronic hepatitis C who have participated in previous Roche or Roche partner protocols. Protocollo in aperto, multicentrico, sulla somministrazione di interferone pegilato alfa-2a (PEGASYS) in monoterapia o in combinazione a ribavirina (COPEGUS) in pazienti affetti da epatite cronica C che hanno partecipato a precedenti protocolli di Roche o di un partner di Roche
To provide treatment or re-treatment with PEGASYS as monotherapy or in combination with COPEGUS, to patients with CHC who participated in a previous Roche or Roche partner protocol where access to tr...
Country
None
organs
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Specialty
None
Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 5 ans
A clinical study with many of countries and sites participating. This study wants to look into the relationship of the genotype IL28B in patients from all over the world which are suffering from an inflammation of the liver with hepatitis C virus
Correlation of Interleukin 28B (IL28B) genotypes rs12979860 (CC vs. TC vs. TT) and rs8099917 (TT vs. GT vs. GG) with liver fibrosis related to CHC
Country
None
organs
None
Specialty
None
unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 5 ans
A phase II/III, multi-center, randomized, 4-week, double-blind, parallel group, placebo and active-controlled trial of the safety and efficacy of RO4917838 vs. placebo in patients with an acute exacerbation of schizophrenia
�Change in Positive and Negative Syndrome Scale (PANSS) total score [ Time Frame: from baseline to Day 28 ] [ Designated as safety issue: No ] � Safety: Incidence adverse events [ Time Frame: 8 week...
Country
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organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 5 ans
A randomized, multicenter phase II study to explore whether biomarkers correlate with treatment outcome in chemo-naive patients with advanced or recurrent non-squamous non-small cell lung cancer, who receive treatment with bevacizumab (at a dose of either 7.5 mg/kg or 15 mg/kg) in addition to carboplatin based chemotherapy (gemcitabine or paclitaxel)
Explore the correlation of biomarkers with response rate as assessed by the investigator (according to RECIST) in patients treated with carboplatin based chemotherapy in combination with 7.5 mg/kg or ...
Country
None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 5 ans
A study to test if aleglitazar has a positive effect on the heart of patients with Type 2 diabetes and without cardiac disease, looking at the way the heart processes energy and fat
To evaluate if aleglitazar improves cardiac energetics, by means of MRS, in uncomplicated T2D patients with no history of CAD, after 6 weeks of treatment
Country
None
organs
None
Specialty
None
Closed trial
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