Study of Ivacaftor in Subjects With Cystic Fibrosis Who Have a Non-G551D CFTR Gating Mutation To evaluate the efficacy of ivacaftor in subjects with cystic fibrosis (CF) who have a non-G551D CFTR gating mutation

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Efficacy of a 12-week Regimen of Telaprevir, Peginterferon, and Ribavirin in Subjects With Interleukin-28B (IL28B) CC Genotype To evaluate the efficacy of a 12-week regimen of telaprevir, Peg-IFN, and RBV in treatment-naive and prior relapser subjects with genotype 1 CHC and IL28B CC genotype

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A Phase 2 Study of VX-950 in Combination With Peginterferon Alfa-2a (Pegasys®), With and Without Ribavirin (Copegus®) in Subjects with Hepatitis C Primary objective: - To assess the proportion of subjects in each group with undetectable plasma HCV RNA, 24 weeks after the completion of the assigned study drug regimen.

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A randomized, double-blind, placebo-controlled, multiple dose study of VX-809 to evaluate safety, pharmacokinetics, and pharmacodynamics of VX-809 in cystic fibrosis subjects homozygous for the deltaF508-CFTR gene mutation To evaluate the safety and tolerability of VX-809 in CF patients who are homozygous for the DeltaF508-CFTR mutation

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A Phase 1, Randomized, Open-label, Single-Dose, Crossover, Relative Bioavailability, and Food-Effect Study of a Pediatric Chewable Tablet Formulation Relative to a 375-mg Core Tablet Formulation of Telaprevir in Healthy Adult Subjects - To determine the bioavailability of telaprevir administered as a pediatric chewable tablet formulation relative to a 375-mg core tablet formulation in the fed state - To evaluate the effect of food...

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Study to compare the effects of VX-787 with placebo against influenza The primary objective of the study is to determine the effect of oral administration of VX 787 administered post-inoculation on the AUC of viral titers quantified by nasal swab cell culture in a human...

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