Program to Give the Drug Aztreonamn Lysine for Inhalation to Canadian Patients with Cystic Fibrosis and infection by the Bacteria Pseudomonas aeruginosa Who Have Limited Treatment Options and are at Risk for Disease Progression The primary objective of this study is to provide expanded access to AZLI 75 mg prior to its commercial availability and establishment of reimbursement programs through Provincial Ministries of Health...

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A randomised controlled study of mouth swab testing versus same-day blood tests for human immunodeficiency virus (HIV) infection in young people attending a young person's community drug service Not provided at time of registration

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Etude GS-US-401-1757 : étude de phase 1b d’escalade de dose, multicentrique visant à évaluer l’innocuité, la tolérance, la pharmacocinétique (PK), la pharmacodynamie et l’efficacité du tirabrutinib associé à l’idélalisib ou à l’entosplétinib, avec ou sans obinutuzumab, chez des patients ayant une hémopathie lymphoproliférative à cellules B en rechute ou réfractaire. Les hémopathies malignes regroupent un ensemble hétérogène de cancers des cellules sanguines et de leurs précurseurs. Parmi cet ensemble, on distingue les leucémies, les syndromes myélodysplasiques et...

• Pays France
• Organes Sang Hématologie - Autres
• Spécialités Thérapies Ciblées, Immunothérapie - Vaccinothérapie

This is a clinical research study involving an experimental drug named GS-6624 for the treatment of metastatic colorectal adenocarcinoma, a sub-type of cancer of the colon and/or rectum. The purpose of this study is to test the effectiveness and safety of GS-6624 at different dose levels when it is given with FOLFIRI. We want to find out what effects, good and/or bad, GS-6624 has on you and your metastatic colorectal adenocarcinoma when it is given with FOLFIRI To compare the additive efficacy of GS-6624 vs. placebo in combination with FOLFIRI as measured by improvement in progression free survival (PFS) in subjects with metastatic KRAS mutant colorectal a...

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The purpose of this study is to evaluate if F/R/TAF works as well as Eviplera. It is also to see if F/R/TAF will maintain the control of your HIV-1 infection when compared to Eviplera. Safety, how well your body accepts the drug, will be evaluated El propósito de este estudio es evaluar si F/R/TAF funciona tan bien como Eviplera. También ver si F/R/TAF mantendrá el control de la infección por VIH-1 comparado con Eviplera. La seguridad, como de bien el cuerpo acepta la medicación, será evaluada To evaluate the non-inferiority of switching to the FTC/RPV/TAF FDC as compared to continuing FTC/RPV/TDF FDC in virologically suppressed HIV-1 infected subjects as determined by maintaining HIV-1 RNA...

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A clinical trial designed to compare how effective ranolazine or drondarone, given either alone or in combination, are in treating sudden, but intermittent, rapid heart beat (atrial fibfillation) To evaluate the effect of ranolazine and of low dose dronedarone when given alone and in combination at different dose levels on AFB over 12 weeks of treatment AFB is defined as the total time a s...

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Viral hepatitis case-finding in primary care Background and study aims Hepatitis B and C are blood-borne viruses that affect the liver. Long-term (chronic) infection with hepatitis B or C (HBV and HCV) is the leading cause of end-stage liver dis...

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A Randomized, Double Blind Study Evaluating Tenofovir Disoproxil Fumarate (DF) Monotherapy Versus the Combination of Emtricitabine and Tenofovir DF for the Treatment of Chronic Hepatitis B •To compare the antiviral efficacy against hepatitis B virus (HBV) of tenofovir DF monotherapy versus tenofovir DF plus emtricitabine combination therapy

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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of E/C/F/TAF Fixed Dose Combination (FDC) in HIV-1 Infected Subjects on Chronic Hemodialysis To evaluate the safety and tolerability of the elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (EVG/COBI/FTC/TAF; E/C/F/TAF) fixed dose combination (FDC) in HIV-1 infected adults with end ...

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A study with sofosbuvir and ribavirin in patients co-infected with HIV and HCV The primary objectives of this study are: • To determine the efficacy of treatment with SOF + RBV as measured by the proportion of subjects with sustained viral response 12 weeks after discontinuatio...

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