A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PHASE 3 STUDY OF SUNITINIB PLUS PREDNISONE VERSUS PREDNISONE IN PATIENTS WITH PROGRESSIVE METASTATIC CASTRATION-RESISTANT PROSTATE CANCER AFTER FAILURE OF A DOCETAXEL-BASED CHEMOTHERAPY REGIMEN To demonstrate superiority in the overall survival (OS) of patients with progressive mCRPC treated with sunitinib plus prednisone (SP) versus placebo plus prednisone (PP) after failure of a docetaxel-...

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PHASE 3, MULTICENTER, LONG-TERM OBSERVATIONAL STUDY OF SUBJECTS FROM TANEZUMAB STUDIES WHO UNDERGO A TOTAL KNEE, HIP OR SHOULDER REPLACEMENT ESTUDIO OBSERVACIONAL A LARGO PLAZO, MULTICÉNTRICO, FASE III, EN PACIENTES DE ESTUDIOS CON TANEZUMAB QUE SE SOMETEN A UNA SUSTITUCIÓN TOTAL DE RODILLA, CADERA U HOMBRO To describe the post-operative outcome of subjects who underwent a total knee, hip,or shoulder replacement while participating in tanezumab Study A4091056, A4091057 or A4091058 (treatment period and s...

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A PHASE 2, RANDOMIZED, PLACEBO CONTROLLED, DOUBLE BLIND PROOF-OF-CONCEPT STUDY OF THE EFFICACY AND SAFETY OF PF-02545920 IN SUBJECTS WITH HUNTINGTON’S DISEASE • To assess the efficacy of 26-week oral daily dosing with PF-02545920 on motor function in subjects with HD.

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A continuation study of CPG 7909 Injection in patients with matastatic or recurrent malignancies who have stable disease or who have responded to CPG 7909 Injection therapy To allow patients who have completed a clinical trial with CPG 7909 Injection or have reached a maximum number of cycles with a combination product (such as chemotherapy) to continue treatment with CP...

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A clinical trial of axitinib plus PF-04856884 or axitinib alone for patients with metastatic renal cancer who have already been treated with an anti-VEGF agent Part I: To confirm that the combination of PF-04856884 and AG-013736 is safe and tolerable at the doses to be used in Part II of the study. Part II: To document clinical activity of the combination...

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Sildenafil Persistent Pulmonary Hypertension of the Newborn (PPHN) follow up study To monitor the developmental progress of PPHN patients treated with sildenafil in study A1481276, 12 and 24 months after completion of sildenafil treatment.

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A clinical trial to assess a novel medicine in the treatment of patients with moderately to severely active rheumatoid arthritis To compare the efficacy of 5 mg BID of tofacitinib (with and without background MTX) to adalimumab with MTX as measured by American College of Rheumatology 50% improvement (ACR50) response rates at Mo...

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A study to test pregabalin in the treatment of patients with painful diabetic peripheral neuropathy and pain on walking There are two co-primary objectives for this study. In patients with painful DPN, to evaluate the efficacy of pregabalin compared to placebo in: 1. The reduction in DPN pain; and 2. The reduction i...

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A clinical trial to determine if the investigational MnB vaccine works when 2 or 3 doses of the vaccine is given to adolescents Co-Primary Objectives: To assess the immune response as measured by serum bactericidal assay performed with MnB strains expressing LP2086 subfamily A and B proteins, measured 1 month after the thi...

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A 12-week, open label, multicentre study assessing the efficcay and of Donepezil in patients discontinuing treatment with Memantine monotherapy To evaluate the efficacy of donepezil on cognition (MMSE) in patients who are currently being treated with memantine, and are switched to donepezil because treatment with memantine is lacking efficacy...

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