Vildagliptin compared to gliclazide as dual therapy with metformin in Muslim patients with type 2 diabetes fasting during Ramadan To evaluate in Muslim patients with T2DM who plan to fast during the Ramadan fasting period: The proportion of patients with at least one HE (Hypoglycaemic event) is lower in the vildagliptin pl...

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Safety and Efficacy of Valsartan vs Atenolol and Hydrochlorothiazide Combination on Blood Flow in Hypertensive Patients This study evaluated the effect of valsartan on small vessel blood flow in patients with mild-to-moderate hypertension in direct comparison to atenolol and hydrochlorothiazide.

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Étude CPKC412E2301 : étude de phase 3 évaluant l'efficacité et la sécurité du midostaurin associé à une chimiothérapie par rapport à un placébo associé à une chimiothérapie chez des patients nouvellement diagnostiqués ayant une leucémie aiguë myéloïde avec une mutation négative FLT3. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] La leucémie aiguë myéloïde est un cancer caractérisé par la multiplication incontrôlée de cellules indifférenciées qui envahissent la moelle osseuse. Cette invasion entraine une baisse dans la product...

• Pays France
• Organes Leucémies aiguës
• Spécialités Chimiothérapie, Thérapies Ciblées

A Multi-Center, Randomized, Double Blind, Placebo-Controlled, ‘add-on’ study to investigate the efficacy and safety of 24 weeks intravenous treatment with QAX576 in patients (≥18-75 years) with persistent asthma not adequately controlled with inhaled corticosteroids and long acting β2-agonists Assess the efficacy of QAX576compared to placebo when added to existing asthma therapy with respect to the Asthma Control Questionnaire (ACQ) score following 24 weeks treatment in patients with inadeq...

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Study of safety and efficacy of PDR001 in combination with dabrafenib and trametinib in patients with a genetically distinct subtype of unresectable or metastatic melanoma, which is characterised by a mutation in the BRAF gene Part 1: Safety run-in To determine the recommended regimen of PDR001 in combination with dabrafenib and trametinib for the randomized part (part 3) Part 2: Biomarker cohort To evaluate changes ...

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A Phase IIIb, Open-Label, Controlled, Multi-Center Study to Evaluate the Persistence Of Antibody Responses Among Children Who Previously Received Novartis MenACWY Conjugate Vaccine or Meningococcal C Conjugate Vaccine Primary: To assess the safety and tolerability of a dose of MenACWY in subjects who were previously vaccinated with one or two doses of MenACWY or MenC. Co-primary: 1.To evaluate the persistence of th...

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An open-label multicenter phase II study of Imatinib mesylate (Glivec) treatment of patients with malignant peripheral nerve sheath tumors To assess response in patients with MPNST treated with Imatinib. Response is defined as at least stable disease according to RECIST criteria.

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An 8-week study to evaluate the efficacy (blood pressure lowering effect) and safety of LCZ696 given alone and in combination with amlodipine To evaluate the blood pressure lowering effect and safety of LCZ696 when given alone and in combination with amlodipine in patients with essential hypertension.

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Efficacy, safety and pharmacokinetics of artemether-lumefantrine dispersible tablet in the treatment of malaria in infants < 5 kg To evaluate the efficacy of a 3-day regimen of artemether-lumefantrine dispersible in infants <5 kg of BW with acute uncomplicated P. falciparum malaria using the polymerase chain reaction (PCR)-corre...

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A Clinical Study to Evaluate Renal Hemodynamic Responses to Aliskiren in Patients With Type 2 Diabetes Mellitus The study objective was to assess the effect of single and multiple doses of aliskiren on renal plasma flow, glomerular filtration rate and to compare the effects of single and multiple do...

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