This is a clinical research study involving an experimental drug named GS-6624 for the treatment of metastatic colorectal adenocarcinoma, a sub-type of cancer of the colon and/or rectum. The purpose of this study is to test the effectiveness and safety of GS-6624 at different dose levels when it is given with FOLFIRI. We want to find out what effects, good and/or bad, GS-6624 has on you and your metastatic colorectal adenocarcinoma when it is given with FOLFIRI To compare the additive efficacy of GS-6624 vs. placebo in combination with FOLFIRI as measured by improvement in progression free survival (PFS) in subjects with metastatic KRAS mutant colorectal a...

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The purpose of this study is to evaluate if F/R/TAF works as well as Eviplera. It is also to see if F/R/TAF will maintain the control of your HIV-1 infection when compared to Eviplera. Safety, how well your body accepts the drug, will be evaluated El propósito de este estudio es evaluar si F/R/TAF funciona tan bien como Eviplera. También ver si F/R/TAF mantendrá el control de la infección por VIH-1 comparado con Eviplera. La seguridad, como de bien el cuerpo acepta la medicación, será evaluada To evaluate the non-inferiority of switching to the FTC/RPV/TAF FDC as compared to continuing FTC/RPV/TDF FDC in virologically suppressed HIV-1 infected subjects as determined by maintaining HIV-1 RNA...

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A clinical trial designed to compare how effective ranolazine or drondarone, given either alone or in combination, are in treating sudden, but intermittent, rapid heart beat (atrial fibfillation) To evaluate the effect of ranolazine and of low dose dronedarone when given alone and in combination at different dose levels on AFB over 12 weeks of treatment AFB is defined as the total time a s...

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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of E/C/F/TAF Fixed Dose Combination (FDC) in HIV-1 Infected Subjects on Chronic Hemodialysis To evaluate the safety and tolerability of the elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (EVG/COBI/FTC/TAF; E/C/F/TAF) fixed dose combination (FDC) in HIV-1 infected adults with end ...

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A study with sofosbuvir and ribavirin in patients co-infected with HIV and HCV The primary objectives of this study are: • To determine the efficacy of treatment with SOF + RBV as measured by the proportion of subjects with sustained viral response 12 weeks after discontinuatio...

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A trial looking at the treatment of Sofosbuvir/Velpatasvir in patients with hepatitis C infection - To evaluate the efficacy of treatment with SOF/VEL fixed dose combination (FDC) for 12 weeks in subjects with chronic HCV infection as measured by the proportion of subjects with sustained viral res...

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A long-term study to follow patients infected with chronic Hepatitis C who received a Gilead Hepatitis C treatment in a Gilead clinical trial The primary objective of this Registry is: - To determine the long-term safety of anti-HCV regimens in the pediatric population as determined by assessments of growth and development.

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A Clinical Trial to Assess the Safety and Efficacy of an Alternating Therapy of Antibiotics with the Drug Aztreonam for Inhalation Solution (AZLI) for the Treatment of Lung Infection by the bacteria Pseudomonas aeruginosa in Patients with Cystic Fibrosis The primary objective of this study is to evaluate the safety and efficacy of a CAT regimen with AZLI and TIS in adult and pediatric subjects with CF and pulmonary PA infection.

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A Multicenter, Double-blind, Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Subjects with Rheumatoid Arthritis - To evaluate the long-term safety and tolerability of filgotinib in subjects who have completed one of the parent studies of filgotinib in RA.

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A trial investigating the safety and efficacy of a drug combination Sofosbuvir/Velpatasvir for subjects with hepatitis C Ensayo para investigar la seguridad y eficacia de la combinación de fármacos sofosbuvir/velpatasvir en pacientes con hepatitis C To evaluate the efficacy of study treatment with Sofosbuvir(SOF)/Velpatasvir(VEL, GS-5816) FDC and SOF/VEL FDC and Ribavirin (RBV) for 12 weeks as measured by the proportion of subjects with sustained...

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