Study is to find out more about evolocumab in HIV-positive patient`s and with high cholesterol (hyperlipidemia and/or mixed dyslipidemia) To evaluate the effect of 24 weeks of subcutaneous (SC) evolocumab administered every month (QM) compared with placebo QM on percent change from baseline in low-density lipoprotein cholesterol (LDL-C)...

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This trial is designed to determine what effects the human body has on the investigational medicine, ABP 710, and what effects the body has on the investigational medicine after you have been given it, and if this is comparable to what is seen for the licensed medicine, infliximab, in patients with moderate or severe rheumatoid arthritis (RA). This study will assess if the investigational medicine is safe and effective in treating moderate or severe RA compared to the licensed medicine. Este ensayo ha sido diseñado para determinar los efectos del cuerpo humano sobre el fármaco experimental, ABP 710, así como los efecto del cuerpo sobre el fármaco en investigación después de haberlo administrado, y verificar si son comparables a los efectos observados con el fármaco aprobado, infliximab, en pacientes con artritis reumatoide (AR) de moderada a grave The primary objective for this study is to assess the efficacy of ABP 710 compared with US-licensed infliximab (infliximab). El objetivo principal de este estudio es evaluar la eficacia de ABP 7...

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AMGEN ASPECCT : Essai de phase 3 randomisé comparant l’efficacité et la tolérance du panitumumab et du cétuximab, chez des patients ayant un cancer colorectal métastatique et non porteur d’une mutation du gène KRAS. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] L’objectif de cet essai est de comparer l’efficacité et la tolérance du panitumumab (Vectibix) à celle du cétuximab (Erbitux), chez des patients ayant un cancer colorectal métastatique et dont la tume...

• Pays France
• Organes Côlon ou Rectum (colorectal)
• Spécialités Thérapies Ciblées

Amgen 2000225 : Essai de phase 2 randomisé, évaluant l'efficacité de l’association paclitaxel, à AMG 706 ou au bévacizumab, en traitement de 1ère ligne, chez des patientes ayant un cancer du sein HER2 négatif, en récidive locale ou métastatique [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] A randomized phase 2 trial of double-blind, placebo controlled AMG 706 in combination with paclitaxel, or open-label bevacizumab in combination with paclitaxel, as first line therapy in women with HER...

• Pays France
• Organes Sein
• Spécialités Chimiothérapie, Thérapies Ciblées

The trial is designed to determine the safety and efficacy of ABP 501 compared with Adalimumab in subjects with moderate to severe rheumatoid arthritis The primary objective for this study is to assess the efficacy of ABP 501 compared with adalimumab.

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A Randomized, Open Label, Active Controlled Study of AMG 162 in Subjects with Advanced Cancer Currently Being Treated with Intravenous Bisphosphonates To determine the effectiveness of AMG 162 in reducing urinary N-telopeptide (uNTx) below 50 nM BCE / mM creatinine in advanced cancer subjects with bone metastases (including multiple myeloma subjects...

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A Randomized, Double-blind, Placebo-controlled, Multiple-dose Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 827 in Subjects with Rheumatoid Arthritis and an Inadequate Response to Methotrexate To evaluate the efficacy of AMG 827 compared with placebo as measured by the proportion of subjects achieving an American College of Rheumatology (ACR) 50 response at week 12.

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Bone Histomorphometry Assessment For Dialysis Patients with Secondary Hyperparathyroidism of End Stage Renal Disease To describe histomorphometric parameters of bone turnover in dialysis subjects with high turnover renal osteodystrophy during treatment with Sensipar®/Mimpara® with or without concomitant vitamin D st...

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• Organes Aucun
• Spécialités Aucune

Amgen 20060439 : Essai de phase 2 randomisé, en double aveugle, évaluant l'efficacité et la tolérance de l'AMG 386 associé au cisplatine et à la capécitabine chez des patients ayant un cancer gastrique métastatique. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] A randomized, double blind, multi-center, phase 2 study to estimate the efficacy and evaluate the safety and tolerability of cisplatin & capecitabine (CX) in combination with AMG 386 or placebo in sub...

• Pays France
• Organes Estomac, Oesophage
• Spécialités Chimiothérapie

A Randomized Open-Label Study to Evaluate the Safety and Efficacy of Denosumab and Ibandronate in Postmenopausal Women Sub-Optimally Treated with Daily or Weekly Bisphosphonates To evaluate the change in total hip Bone Mineral Density (BMD) at 12 months in postmenopausal women transitioning from previous daily or weekly bisphosphonate therapy to denosumab 60 mg SC Q6M compare...

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