The RASCAL study (refractory angina spinal cord stimulation and usual care) Background and study aims Coronary heart disease (CHD), also known as ischemic heart disease, is one of the leading causes of death worldwide. CHD develops because of the build-up of fatty deposits (p...

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Improvement of pain and quality of life in patients with sickle cell disease with overnight oxygen therapy or auto-adjusting positive airway pressure (APAP) Background and study aims Sickle cell disease (SCD) is an inherited blood disorder where the red blood cells do not develop normally. Instead of being flexible and disc-shaped like normal blood cells,...

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HOPE: Help for people with money, employment and benefit problems Background and study aims Economic recessions are usually characterised by rises in unemployment, debt and increased home repossession. They are also often accompanied by increases in the rate of of s...

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Pilot trial comparing different fluid amounts given in the earliest stages of treatment in children presenting to UK emergency departments with a severe infection Background and study aims Septic shock is a life-threatening condition in which the blood pressure drops to dangerously low levels because of a serious blood infection (sepsis). Children are now much ...

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PATHS to success: Evaluating the efficacy of the Promoting Alternative Thinking Strategies (PATHS) curriculum in promoting social and emotional wellbeing among children in primary school Background and study aims This five-year project will evaluate the effectiveness of a primary school based intervention called Promoting Alternative Thinking Strategies (PATHS). PATHS helps children m...

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Methylnaltrexone for the treatment of opioid induced constipation Background and study aims The drug methylnaltrexone is approved for use in the palliative/end of life care setting for treating constipation caused by opioid drugs. We believe that the use of methyln...

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A spectral analysis of human brain tissue Not provided at time of registration

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Reducing unnecessary admissions for chest pain with the Manchester Acute Coronary Syndromes (MACS) decision rule Background and study aims When people suffer from chest pain we are often worried that the pains may be coming from a heart problem such as a heart attack. It is often difficult to tell quickly if a p...

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Bowel cancer screening information: your response Background and study aims In England, the NHS Bowel Cancer Screening Programme (BCSP) offers screening to over 60 year olds. This involves completing a stool sample test at home. Recent data suggests ...

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Preparing people with difficulties consistent with a personality disorder for employment Background and study aims In January 2013, 1.43 million people in the UK received incapacity benefit, many because of mental health difficulties. There is a complex relationship between employment and...

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