A study to compare combination regimen with vildagliptin & metformin versus metformin in treatment-naive patients with type 2 diabetes mellitus - Demonstrate the superiority of combination of vildagliptin 50mg bid and metformin over metformin monotherapy in treatment-naive patients with T2DM by testing the hypothesis that the risk of initial ...

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A clinical research study evaluating the possibility to stop the drug nilotinib (Tasigna) in chronic myeloid leukemia (CML) patients who have very small amount of leukemia cells remaining after nilotinib (Tasigna) treatment The purpose of this study is to determine the rate of successful treatment-free remission (TFR) within the first 48 weeks following cessation of treatment in patients who achieved and maintained a mol...

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An open-label, randomized, multicenter safety study to evaluate the skeletal and lipid profile effects of letrozole and tamoxifen in postmenopausal women with resected, receptor positive early breast cancer The primary objective of this study is to assess the effect of letrozole versus tamoxifen on the bone mineral density (BMD) of the lumbar spine (L2 to L4) as measured by dual energy X-ray absorptiome...

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A Phase 2, Open-Label, Single-Center, Extension Study Evaluating Antibody Persistence compared to Naïve Children and Safety, Tolerability and Immunogenicity of a Booster Dose of Novartis rMenB±OMV NZ Vaccine in Healthy UK Children Who Previously Received a Three-Dose Series of the Novartis Vaccine as Infants in Study V72P9 The present study, V72P9E1, is an extension of V72P9. The primary objective of this extension study will be to evaluate bactericidal antibody persistence at approximately 40 months of age in subjects ...

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A multicenter, randomized, double-blind, parallel-group study to investigate the glucose lowering effect, safety and tolerability of a 24 week treatment with Vildagliptin 100 mg o.a.d. versus placebo followed by a 12 week treatment period with open-label Vildagliptin 100 mg o.a.d. as add-on therapy in patients with type 2 diabetes inadequately controlled with Metformin monotherapy To confirm the efficacy of vildagliptin 100 mg add-on therapy in patients with type 2 diabetes inadequately controlled with prior metformin monotherapy by testing the hypothesis that the HbA1c reducti...

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This study is to allow continued access to QTI571 for patients who received QTI571 for pulmonary arterial hypertension in one of the long-term extension studies (A2301E1, A2102E1 and E2203) and have been judged by the investigator to benefit from continued QTI571 treatment. Este estudio tiene como objetivo permitir la continuación del acceso a QTI571 en pacientes que hayan recibido QTI571 para la hipertensión arterial pulmonar en uno de los estudios de extensión a largo plazo (A2301E1, A2102E1 y E2203) y que el investigador considere que se beneficiarán de la continuación del tratamiento con QTI571 To provide continued treatment to PAH patients who are benefitting from treatment with QTI571 Facilitar la continuación del tratamiento a los pacientes con HAP que se beneficien del tratamiento ...

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A one year open label, non comparative extension to a randomised, multicentre, phase II study to evaluate the asfety, tolerability, pharmacokinetics and effects on iron concentration of repeated doses of 5-10 mg/kg/day of ICL670 relative to deferoxamine in sickle cell disease patients with transfusional hemosiderosis Evaluate the long-term safety and tolerability profile of ICL670 in sickle cell disease patients with transfusional iron overload requiring chelation therapy

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An open-label, randomized phase II study to evaluate the efficacy of AUY922 vs pemetrexed or docetaxel in NSCLC patients with EGFR mutations Ensayo abierto, aleatorizado, fase II para evaluar la eficacia de AUY922 frente a pemetrexed o docetaxel en pacientes con NSCLC con mutaciones en el EGFR To compare PFS in patients with advanced NSCLC whose tumors harbor EGFR activating mutations and have progressed on EGFR TKI treatment treated with AUY922 versus pemetrexed or docetaxel. Compara...

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Understanding the mechanism of the acute phase response following intravenous (IV) bisphosphonates and its prevention: a study of the effects of zoledronic acid and co-prescription with fluvastatin or placebo Not provided at time of registration

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A Study to Assess the Efficacy of Inhaled Corticosteroid (ICS) Therapy in Moderate-Severe Bronchial Asthma The purpose of this study is to investigate/assess the treatment of moderate to severe asthmatics with inhaled corticosteroid.

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