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Kusajili – Centralise les essais cliniques mondiaux
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de votre recherche span> par promoteur : Novartis Pharma GmbH
Femme et Homme Max 99 ans
Novartis Pharma GmbH
MAJ Il y a 5 ans
A randomized, 24-week, double-blind, placebo-controlled, parallel-group, multicenter study to assess the efficacy and safety of Omalizumab in adult patients with chronic urticaria who exhibit IgE against thyreoperoxidase
To demonstrate that omalizumab, compared to omalizumab-Placebo, has superior efficacy as for urticaria activity score (UAS7) after 24 weeks of treatment in adult patients with moderate to severe chro...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Novartis Pharma GmbH
MAJ Il y a 5 ans
Comparison of Lucentic (Ranibizumab) and Ozurdex (Dexamethasone) for the treatment of patients with visual impairment due to macular edema following branch retinal vein occlusion
The primary objective is to show that ranibizumab (administered in an individualized treatment regimen) has superior efficacy and safety compared to Dexamethasone implant (Ozurdex®) over a 6 months pe...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Novartis Pharma GmbH
MAJ Il y a 5 ans
Multi-center, open-label, prospective, randomized, parallel group, long-term study investigating a standard regimen in de novo kidney transplant patients versus a CNI-free regimen and a CNI-low dose regimen
The primary objective of this trial is to demonstrate superiority of a CNI-free regimen respect to the renal function at Month 12 post Tx assessed by glomerular filtration rate – Nankivell method – as...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Novartis Pharma GmbH
MAJ Il y a 5 ans
Comparison of systemic VEGF protein dynamics following monthly intravitreal injections of 0.5 mg ranibizumab versus 2 mg aflibercept in patients with visual impairment due to diabetic macular edema
To compare systemic VEGF-A protein levels following monthly intravitreal injections of 0.5 mg ranibizumab versus 2 mg aflibercept as measured by the area under the curve (AUC) from baseline to study w...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Novartis Pharma GmbH
MAJ Il y a 5 ans
Measurement of Patient Reported Gastrointestinal (GI) and Health-related Quality of Life (HRQL) Outcomes in Simultaneous Pancreas-Kidney Transplant Recipients
To assess if a switch from MMF to myfortic® results in improved GI- and/or health-related quality of life outcomes, and to determine the proportion of SPK transplant recipients who are experiencing an...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Novartis Pharma GmbH
MAJ Il y a 5 ans
Combination of antiangiogenic therapy using the mTOR-inhibitor RAD001 and low dose chemotherapy for locally advanced and/or metastatic pancreatic cancer – a dose finding study
To determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of escalating doses of Gemcitabine in combination with Everolimus.
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Novartis Pharma GmbH
MAJ Il y a 5 ans
An open-label, randomized, parallel group study comparing the efficacy and safety of Amlodipine in combination with Valsartan compared to Losartan in combination with Hydrochlorothiazide given for 52 weeks on the regression of left ventricular hypertrophy in patients with mild-to-moderate hypertension
To demonstrate a noninferior or superior efficacy of the combination of valsartan 160mg and amlodipine 5mg compared with the combination of losartan 100mg and HCTZ 12.5mg by testing the hypothesis tha...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Novartis Pharma GmbH
MAJ Il y a 5 ans
Localized gastrointestinal stromal tumors (GIST): an exploratory open-label, multicenter, single-arm phase II study to evaluate the efficacy of 2 years of adjuvant nilotinib treatment following at least 1 year of adjuvant imatinib mesylate
To evaluate the activity of nilotinib in patients with localized GIST who have undergone R0 or R1 resection and who have been treated with imatinib for at least 12 months in an adjuvant setting.
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Femme et Homme Max 99 ans
Novartis Pharma GmbH
MAJ Il y a 5 ans
„Effect of intravenous Zoledronic Acid on Bone Metabolism given over 4 month in patients with prostate cancer or breast cancer and bone metastasis. A prospective, single-arm multicenter study” (ZoTect)
To assess course of bone turn-over markers (PINP, bALP, ICTP and CTX)
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Novartis Pharma GmbH
MAJ Il y a 5 ans
Multi-center, open-label, prospective, randomized, parallel group study investigating an intensified Myfortic® dosing regimen in comparison to a standard dosing regimen of Myfortic® in combination with Sandimmun® Optoral and Corticosteroids in de novo renal transplant patients
This exploratory study will be conducted in two phases to compare in terms of safety and efficacy an initially intensified dosing regimen of Myfortic® versus a standard dosing regimen of Myfortic®. ...
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Essai clos aux inclusions
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