A study to understand the safety and effectiveness of a new drug called TAF for the treatment of long term hepatitis B infection in adolescents Part A: -To evaluate the steady state pharmacokinetics (PK) of tenofovir alafenamide (TAF) and confirm the dose of TAF 25 mg tablet given once daily in treatment-naïve and treatment-experienced adoles...

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A trial investigating the safety and efficacy of the drug combination Sofosbuvir/Velpatasvir/GS-9857 for 8 weeks against Sofosbuvir/Velpatasvir for 12 weeks for subjects with hepatitis C To determine the efficacy of treatment with sofosbuvir (SOF)/velpatasvir (VEL)/GS-9857 fixed dose combination (FDC) for 8 weeks and of treatment with SOF/VEL FDC for 12 weeks as measured by the propor...

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A Open-Label, Parallel-Group, Exploratory Study to Evaluate the Efficacy and Safety of 400 µg Regadenoson Bolus for Pharmacological Stress Echocardiography To evaluate the efficacy of a 400 µg regadenoson bolus for pharmacological stress echocardiography by comparing the stress echocardiographic images obtained after dobutamine with those obtained after ...

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A trial looking at the treatment of SOF/GS-5816 for 12 weeks in patients with hepatitis C infection The primary objectives of this study are: - To evaluate the efficacy of treatment with SOF/GS-5816 for 12 weeks in subjects with chronic HCV infection as measured by the proportion of subjects wit...

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A study looking at 12 weeks treatment with GS-7977 + Ribavirin for patients with chronic genotype 2 or 3 Hepatitis C infection who previously took part in Gilead-sponsored GS-7977 studies in the control arms The primary objectives of this study are: • To determine the efficacy of GS-7977 + RBV as measured by the proportion of subjects with sustained viral response at 12 weeks after discontinuation of the...

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A Clinical trial to evaluate safety, and effectiveness of Selonsertib in Subjects with Compensated Cirrhosis due to Nonalcoholic Steatohepatitis (NASH) Estudio para evaluar la seguridad y la eficacia de selonsertib en pacientes con cirrosis compensada debida a esteatohepatitis no alcohólica (EHNA) The primary objective of this study is: To evaluate whether SEL can cause fibrosis regression and reduce associated complications in subjects with cirrhosis due to NASH. Objetivo principal: Eval...

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This study will test an experimental drug named GS-9883/Emtricitabine/Tenofovir Alafenamide (GS-9883/F/TAF) for the possible treatment of human immunodeficiency virus (HIV) infection in children and adolescents. The purpose of this study is to determine the concentration of GS-9883 in your child’s body, and confirm the safety, tolerability and dose of GS-9883/F/TAF in HIV-1 infected, virologically suppressed adolescents (12 to < 18 years of age) and children (6 to < 12 years of age) The primary objectives of this study are: - To evaluate the steady state pharmacokinetics (PK) for GS-9883 and confirm the dose of the GS-9883/emtricitabine/tenofovir alafenamide (GS-9883/F/TAF) fixed...

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A study evaluating the Safety and Efficacy of Entospletinib (GS-9973) in combination with standard of care in adult subjects with Relapsed or Refractory Acute Lymphoid Leukemia (ALL) To evaluate safety of entospletinib (GS-9973) in combination with vincristine (VCR) and dexamethasone in adult subjects with previously treated relapsed or refractory B-cell lineage ALL

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A study of GS-7977 and Ribavirin in patients with HCV waiting for a liver transplant Ensayo de GS-7977 y Ribavirina en pacientes con VHC que esperan un transplante de hígado The primary objective of this study is to determine if the administration of a combination of GS-7977 and ribavirin to HCV-infected subjects with hepatocellular carcinoma (HCC) meeting the MILAN crite...

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A study to compare a pediatric tablet or suspension of elvitegravir verses the adult 150 mg tablet in healthy adult volunteers The primary objective of this study is to evaluate the relative bioavailability of two age-appropriate pediatric formulations (tablet and suspension formulation) of EVG co-administered with ritonavir ...

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