Woman and Man
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Extract
1. To determine the efficacy of RO0506997 (a dual α4 integrin [VCAM1] antagonist) in combination with methotrexate, in adult patients with rheumatoid arthritis (RA) who currently exhibit a partial clinical response to their existing methotrexate therapy. 2. To determine the safety of RO0506997 (a dual α4 integrin [VCAM1] antagonist) in combination with methotrexate, in adult patients with rheumatoid arthritis (RA). 3. To explore the pharmacokinetics (PK) of RO0506997 (in combination with methotrexate) in this population of patients, utilising a population pharmacometric approach. 4. To explore the pharmacodynamics (PD) of RO0506997 (in combination with methotrexate) in this population of patients.
Inclusion criteria
- Rhematoid Arthritis