SCORE An open, randomised, parallel, three treatment groups, multicentre, phase IV study - in real life - to compare the change in social outcome of quetiapine fumarate (Seroquel®) combined with Cogni...

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Reference: EUCTR2005-000258-64

SCORE An open, randomised, parallel, three treatment groups, multicentre, phase IV study - in real life - to compare the change in social outcome of quetiapine fumarate (Seroquel®) combined with Cognitive Remediation Therapy to conventional treatment in patients with schizophrenia

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Extract

The primary objective of this study is to compare efficacy of quetiapine fumarate (hereafter called quetiapine) combined with Cognitive Remediation Therapy (CRT) to conventional treatment by evaluating change in social outcome, from baseline (visit 1) to the end of CRT (visit 3), in patients with schizophrenia, assessed by Strauss-Carpenter scale.


Inclusion criteria

  • Schizophrenia is a chronic psychiatric disorder that often begins during adolescence or early adulthood. A major problem for patients with schizophrenia is a cognitive deficit compared to a control group of healthy. It is generally accepted that a patient’s cognitive ability is closely correlated with clinical outcome. It can be concluded that patients have very poor cognition in acute psychotic episodes depending on treatment with high doses of antipsychotic drugs

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