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An exploratory study of the effects of Imatinib on allergic inflammation following out of allergy season repeated nasal allergen challenge in subjects with seasonal allergic rhinitis sensitive to Timo...

Update Il y a 4 ans
Reference: EUCTR2006-004722-82

An exploratory study of the effects of Imatinib on allergic inflammation following out of allergy season repeated nasal allergen challenge in subjects with seasonal allergic rhinitis sensitive to Timothy grass pollen – an exploratory study of c-kit inhibition in allergic respiratory diseases

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Extract

To assess the effects of Imatinib on allergic inflammation following repeated nasal allergen challenge (NAC) in subjects with seasonal allergic rhinitis sensitive to Timothy grass pollen – in particular to assess if Imatinib reduces mast cell degranulation (measured by β-tryptase and PGD2) in response to allergen challenge

Inclusion criteria

  • Seasonal Allergic Rhinitis (sensitivity to Timothy grass pollen)

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