A Study to Explore the Mechanism of Action of Ocrelizumab and B-cell Biology in Patients with Relapsing Multiple Sclerosis

Update Il y a 4 ans
Reference: EUCTR2015-004616-37

Woman and Man

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Extract

• To understand the impact of ocrelizumab treatment on neurofilament light (NfL) as a biomarker of neuronal damage in cerebrospinal fluid (CSF) • To assess the number of cluster of differentiation (CD)19+ B cells in CSF (cell number/microliter) before and after treatment with ocrelizumab • To assess the number of CD3+ T cells in CSF (cell number/microliter) before and after treatment with ocrelizumab


Inclusion criteria

  • Relapsing Multiple Sclerosis