The influence of renal function on the amount of nadroparin in blood Anti-Xa levels will be measured 4 hours (± 1 hour) after subcutaneous injection of nadroparin on day 1 or day 2, day 3 and day 5 of treatment (if applicable day 10 of treatment). Primary outcome is th...

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Study of Pharmacokinetic-guided dosing of clottiing factor in Hemophilia. Studie naar farmacokinetisch gestuurde toediening van stollingsfactoren in hemofilie 1. To investigate whether peri-operative dosing using a population-based pharmacokinetic model (non-linear mixed effect modelling) in hemophilia patients leads to a significant reduction in clotting f...

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Pharmacokinetics of IVIg treatment in patients with CIDP Farmacokinetiek van IVIg behandeling bij patiënten met CIDP The main objective of the study is to determine the PK and PD of IVIg during maintenance treatment in patients with CIDP. These data will be used to conduct a NONMEM analysis in relation to the dosag...

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Study to look at the usefulness of an extra dose of salbutamol (medicine that widens the airways in the lungs) through the bloodstream, in children who are admitted to an intensive care for a very severe asthma-attack. Een studie om te kijken of het nuttig is om een extra dosis salbutamol te geven (medicijn dat de luchtwegen wijder maakt in de longen) via het bloed, bij kinderen die op een intensive care liggen voor een heel ernstige astma-aanval To assess the efficacy of a loading dose of intravenous salbutamol in children admitted to a PICU for severe acute wheeze or severe acute asthma. Efficacy is measured by the reduction in asthma score ...

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Chemotherapy followed by surgery versus surgery alone in high-risk patients with resectable colorectal liver metastases The CHARISMA randomized multicenter clinical trial Chemotherapie gevolgd door chirurgie versus chirurgie alleen in hoog-risico patienten met resectabele colorectale levermetastasen De CHARISMA gerandomiseerde multicenter trial The primary objective of the study is to compare the efficacy, as assessed by overall survival (OS), of surgery and neo-adjuvant chemotherapy to surgery alone in patients with liver metastases of colo...

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Azacitidine in children with MDS or JMML Azacitidine in Kinderen mit MDS oder JMML To establish the recommended dose and preliminary efficacy of azacitidine in children with newly diagnosed and relapsed advanced MDS or JMML. Ermittlung der empfohlenen Azacitidin-Dosis und vor...

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Factors affecting food choices of older adults from high and low socioeconomic groups Background and study aims People often chose the food they eat according to how healthy it is, how much it costs and convenience. However, it is not really known to what extent an older persons socio...

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ALA-PDT for premalignant vulvar disorders. ALA-PDT voor premaligne vulva aandoeningen To assess the efficacy of low dose rate light fractionated aminolevulinic acid-Photodynamic Therapy (ALA-PDT) for treatment of usual type Vulvar Intraepithelial Neoplasia (uVIN) and lichen sclerosus (...

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Pneumonia obtained by mechanical ventilation: investigation whether adding inhalation antibiotics with tobramycin to standard intravenous antibiotic treatment is better than intravenous antibiotic treatment alone Does addition of inhalation tobramycin to standard IV treatment result in a higher clinical cure rate than standard IV antibiotic treatment alone in patients with ventilator-associated pneumonia. The...

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Maternal, uteroplacental and fetal haemodynamic effect of Nicardipine in severe pre-eclampsia To investigate in detail the haemodynamic effects of antihypertensive treatment with Nicardipine of a hypertensive crisis in patients with severe pre-eclampsia. The effects will be investigated by mat...

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