Revaccination with Pneumococcal Conjugate Vaccine - Characterization of the Immune Response after Polysaccharide (REPLAY) To characterize the immune response by ELISA and OPA at approximately one month after vaccination to a single dose of PCV13 challenge in children vaccinated with a primary series (3 or 2 doses) of PCV...

• Country None
• organs None
• Specialty None

A Postauthorization Safety Surveillance Study of Patients Switching to ReFacto AF From ReFacto or Other Factor VIII Products in Usual Care Settings To evaluate clinically significant FVIII inhibitor development in a large number of severe hemophila A patients treated with ReFacto AF in usual use settings.

• Country None
• organs None
• Specialty None

Randomized, Parallel, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of SBI-087 in Seropositive Subjects With Active Rheumatoid Arthritis on a Stable Background of Methotrexate To evaluate clinical efficacy and safety of 4 SBI-087 SC dosing regimens versus placebo in seropositive subjects with active RA on a stable background of MTX

• Country None
• organs None
• Specialty None

A 3-MONTH, RANDOMIZED, DOUBLE-BLIND, PLACEBO- CONTROLLED, MULTICENTER, SAFETY, TOLERABILITY, AND EFFICACY STUDY OF 3 DOSES OF SRA-333 IN OUTPATIENTS WITH MILD TO MODERATE ALZHEIMER’S DISEASE WITH DONEPEZIL AS ACTIVE CONTROL The primary objective is to determine the safety, tolerability, and efficacy of 3 doses of SRA-333 in patients with mild to moderate AD over 12 weeks.

• Country None
• organs None
• Specialty None

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of Intravenous Methylnaltrexone (MOA-728) for the Treatment of Postoperative Ileus After Ventral Hernia Repair The primary objective of this study is to assess the efficacy of IV MOA-728 in subjects who have undergone repair of large (³10 cm) ventral hernias, with or without a mesh prosthesis via laparotomy or...

• Country None
• organs None
• Specialty None

A Safety Study of TDS-943 Safety - to assess Gastric Mucosal Prostaglandin Synthesis between comparitors

• Country None
• organs None
• Specialty None

Wyeth 3066K1-404 : Essai de phase 2-3 randomisé évaluant l'efficacité et la tolérance du temsirolimus et du sorafénib, en traitement de second ligne, chez des patients ayant un cancer du rein. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] A Randomized Trial of Temsirolimus Versus Sorafenib as Second-Line Therapy in Patients With Advanced Renal Cell Carcinoma Who Have Failed First-Line Sunitinib Therapy.

• Country France
• organs Rein
• Specialty Thérapies Ciblées

Randomized Open-label Study Comparing 2 Different Strategies For Management of Subjects With Plaque Psoriasis Who Have Responded to Etanercept Treatment To describe the effect on subjects in whom PSO has responded to initial treatment with ETN of 2 different strategies for managing a good response or complete response (PGA = 1or 0) over a 52-week time...

• Country None
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• Specialty None

A phase 3 randomized, placebo-controlled, double-blind study of oral CCI-779 administered in combination with letrozole vs. letrozole alone as first line hormonal therapy in postmenopausal women with locally advanced or metastatic breast cancer Assessment of overall progression free survival (PFS)

• Country None
• organs None
• Specialty None

A Randomized Double-Blind Placebo Controlled Trial Evaluating the Safety and Efficacy of Etanercept 25 mg Twice Weekly in Subjects with Moderate to Severe Persistent Asthma To assess the efficacy and safety of etanercept 25 mg twice weekly in subjects with moderate to severe persistent asthma

• Country None
• organs None
• Specialty None