A clinical trial undertaken around the world in adult patients with excessive daytime sleepiness . These patients are randomly given a drug or an inactive drug to increase their ability to stay awake throughout the day To evaluate the efficacy of JZP-110 administered once daily for up to 12 weeks in doses of 75, 150, and 300 mg compared to placebo in the treatment of excessive sleepiness in adult subjects with narco...

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Single- and Multiple-Dose Study to Compare the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Sodium Oxybate (Xyrem®) in Subjects with Moderate to Severe Essential Tremor To determine the relationship between drug plasma levels and safety, tolerability, and efficacy in subjects with moderate to severe essential tremor after single and multiple doses of sodium oxybate.

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A Randomized, Double-Blind, Placebo-Controlled, Safety and Efficacy Study of Xyrem® (sodium oxybate) in Subjects with Fibromyalgia To evaluate the safety and efficacy of Xyrem (sodium oxybate) oral solution at 4.5 g/night and 6 g/night compared to placebo for the treatment of fibromyalgia in a randomized, double-blind, placebo co...

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Study of the Efficacy and Safety of Xyrem in Pediatric Subjects with Narcolepsy with Cataplexy Primary objectives are: 1) To evaluate the efficacy of Xyrem (sodium oxybate) oral solution in the treatment of cataplexy in pediatric subjects with narcolepsy 2) To evaluate the safety of Xyrem in ...

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A long term clinical trial undertaken around the world in adult patients to treat Excessive Sleepiness in Subjects with Narcolepsy or Obstructive Sleep Apnea To evaluate the safety and tolerability of JZP-110 administered once daily for up to 52 weeks in doses of 75, 150, and 300 mg.

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A clinical trial undertaken around the world for treating excessive daytime sleepiness in subjects with obstructive sleep apnea. These patients are randomly given a drug or an inactive drug to increase their ability to stay awake throughout the day To evaluate the efficacy of JZP-110 administered once daily for up to 12 weeks in doses of 37.5, 75, 150, and 300 mg compared to placebo in the treatment of excessive sleepiness in adult subjects with...

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A Phase 2a, Open-label, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Intranasal Clonazepam in Adult Subjects with Epileptic Seizures To determine the minimum effective dose (MED) of intranasal clonazepam, defined as the lowest dose that can effectively reduce epileptiform activity in adult epilepsy subjects over the 24 hours follow...

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Study of the Effect of JZP-258 in Patients with Cataplexy and Narcolepsy To evaluate the efficacy of JZP-258 in the treatment of cataplexy in subjects with narcolepsy

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A clinical study to investigate the efficacy and safety of Defibrotide compared with Best Supportive Care in the prevention of Hepatic Veno-Occlusive Disease in adult and pediatric patients Undergoing Hematopoietic Stem Cell Transplant. Ensayo clínico para investigar la eficacia y seguridad de Defibrotide en comparación con el mejor tratamiento de soporte en la prevención de la enfermedad venooclusiva hepática en pacientes adultos y pediátricos sometidos a un trasplante hematopoyético de células madre The primary objective of the study is to compare the efficacy of defibrotide vs Best Supportive Care for the prevention of Veno-Occlusive Disease (VOD) as measured by VOD-free survival by Day +30 post...

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Treatment of excessive sleepiness in adult patients with obstructive sleep apnea; to increase the ability to stay awake throughout the day To evaluate the efficacy of JZP-110 administered once daily compared to placebo in the treatment of excessive sleepiness in adult subjects with OSA.

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• Specialty None