Extrait

Background and study aims Root caries are cavities that form on the roots of the teeth. Xerostomia (dry mouth) is considered as a primary cause for root caries in older people, as the reduction in saliva flow and resulting increase in mouth acidity leads to loss of minerals from the tooth surface. CPP-ACP is a type of protein derived from milk that enhances the action of fluoride. The aim of this study is to test two different dental varnishes containing fluoride with or without CPP-ACP for the treatment of root caries in patients with xerostomia. Who can participate? Patients aged 18 and over attending the Dry Mouth clinic at the Barts and The London Dental hospital or the Diabetic clinic. What does the study involve? The participants are randomly divided into two groups. One group is treated with dental varnish containing fluoride. The other group is treated with dental varnish containing fluoride and CPP-ACP. At the start of the study all participants undergo assessments of mouth dryness, saliva, root caries and plaque, and the varnish is applied. The saliva test, root caries and plaque assessment and varnish application are repeated at follow-up visits are after 3, 6 and 12 months. What are the possible benefits and risks of participating? Participants will benefit from a clinical examination of their mouth which will verify if they are suffering from oral dryness or root decay. Participants will receive varnish application which is a pain-free treatment, oral hygiene instructions, and free standard toothpastes with medium toothbrushes during the study period. There are no reported side effects related to the use of dental varnishes for the management of tooth decay. The only issue is that the dental varnish may fail to manage your root decay, subsequently either restorative treatment (“drilling and filling”) or extraction of the decayed tooth may be required. Where is the study run from? NHS Trust, Barts and The London Dental Hospital, School of Medicine and Dentistry (UK) When is the study starting and how long is it expected to run for? June 2016 to January 2018 Who is funding the study? Queen Mary University of London (UK) Who is the main contact? Dr Ahmed Mustafa [email protected]

Critère d'inclusion

• Root caries

Liens

• ictrp
• isrctn