Extrait

Background and study aims Urinary tract infections (UTIs) are very common infections in women. For women with UTIs which happen more than twice a year, low dose antibiotic prophylaxis (preventative treatment) for several months can be recommended. However, this can lead to resistance of not only the bacteria responsible for the UTI but also of all the natural bacterial found on/in a healthy person. Previous studies have demonstrated that prophylaxis with non-antibiotic compounds (lactobacilli oral therapy) compared with a dummy treatment may lead to a lower number of new UTI episodes. Cranberry juice, compared with a dummy treatment, has also resulted in fewer UTIs in women. This study aims to compare these forms of non-antibiotic prophylaxis to antibiotic prophylaxis. Who can participate? Women who have an indication for prophylaxis of recurrent UTIs. What does the study involve? Participants will be randomly allocated to one of four treatments. In study A, 280 pre-menopausal women will receive either cranberry capsules or standardized antibiotic treatment. In study B, 280 postmenopausal women will receive either lactobacilli oral therapy or standardized antibiotic treatment. Each month, during 15 months, all patients have to fill in a short questionnaire and to collect urine, faeces and a vaginal swab. At the beginning of the study and after 6,12 and 15 months they will have to fill in a longer questionnaire about quality of life. What are the possible benefits and risks of participating? Not provided. Where is the study run from? Academic Medical Center, Amsterdam, the Netherlands. When is the study starting and how long is it expected to run for? September 2005 to September 2009 Who is funding the study? The work was supported by the Netherlands Organization for Health Research and Development Who is the main contact? [email protected]

Critère d'inclusion

• Urinary Tract Infections

Liens

• isrctn
• ictrp