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A Randomized, Double-Blind, Active-Controlled, Multicenter Study of Patients with Cardiovascular Disease and Diabetes Mellitus Not Adequately Controlled with Simvastatin 20 mg or Atorvastatin 10 mg: A...

Mise à jour : Il y a 4 ans
Référence : EUCTR2008-007689-52

A Randomized, Double-Blind, Active-Controlled, Multicenter Study of Patients with Cardiovascular Disease and Diabetes Mellitus Not Adequately Controlled with Simvastatin 20 mg or Atorvastatin 10 mg: A Comparison of Switching to a Combination Tablet Ezetimibe/Simvastatin (10mg/20mg) Versus Switching to Rosuvastatin 10mg or Doubling the Statin Dose

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Extrait

In patients with cardiovascular disease (CVD) and diabetes mellitus treated with simvastatin 20 mg or atorvastatin 10 mg with LDL-Cholesterol blood level (LDL-C) ≥70 mg/dl (1.81 mmol/L) and ≤160 mg/dl (4.14 mmol/L) at baseline: 1. to assess the incremental LDL-C percentage reduction by switching to ezetimibe/simvastatin (10mg/20mg) compared to doubling the baseline statin dose. 2. to evaluate the safety of ezetimibe/simvastatin (10mg/20mg) versus statin at double the baseline dose and rosuvastatin 10 mg.

Critère d'inclusion

  • Lipids not at goal in diabetic patients with cardiovascular disease

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