Femme et Homme
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Extrait
To evaluate the effect of etanercept 50 mg once weekly for 24 weeks and etanercept 50 mg twice weekly for 12 weeks followed by etanercept 50 mg once weekly for 12 weeks in treating the skin manifestations of psoriasis in subjects with moderate to severe psoriasis when used with adjunctive topical therapy as needed.The primary hypothesis is that etanercept 50 mg once weekly will provide a Psoriasis Area and Severity Index (PASI) 75 response (75% improvement from baseline in PASI) of at least 50% at week 24 when used with adjunctive topical therapy as needed. The conditional primary hypothesis is that etanercept 50 mg twice weekly followed by etanercept 50 mg once weekly will provide a PASI 75 response of at least 60% at week 24 when used with adjunctive topical therapy as needed.
Critère d'inclusion
- Moderate to Severe Plaque Psoriasis