Woman and Man
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Extract
The overall aim of the study is to determine which downstream cellular and molecular pathways involved in PsA pathogenesis are modulated by IL23/12 P40 blockade. As we have ample evidence that relevant disease-specific pathways are found in the primary target tissues, in particular in synovial tissue obtained from peripheral joints, but not in peripheral blood, we will strongly focus on this compartment by obtaining paired biopsies before and after treatment The primary objective is to assess the effect of IL23/12 P40 blockade on: - the global synovial histology and inflammatory infiltration - the number and type of IL-17 producing cells in PsA synovitis - the production of inflammatory mediators (including IL-17 related cytokines such as IL-22, and pther pro-inflammatory cytokines such as TNF) by total synovial tissue biopsies (ex vivo culture system) as well as by peripheral blood cells - the synovial stromal cell signature - the pan-genomic synovial gene expression profile
Inclusion criteria
- Psoriatic Arthritis,artritis psoriatica