A Double-Blind, Placebo-Controlled, Randomized, Single-Dose, 2-Period Crossover Study of the Pharmacodynamics of Orally Administered PSI-697 in Healthy Subjects Who Smoke

To assess the pharmacodynamics (PD) of a single oral dose of PSI-697 in healthy subjects who smoke.

PSI-697 is an orally active inhibitor of the cellular adhesion molecule P-selectin that offers a unique, first in class mechanism for preventing the vascular atherothrombotic state that is driven by the accumulation leukocytes and platelets in the vascular wall