Extrait

To determine whether and how age affects vaccine-induced immune responses, a vaccination trial in volunteer participants will be performed using a licensed vaccine for primary immunization to protect against TBE. The study will include two groups: 1) healthy young adults 18-30 years old and 2) older adults, 60 years or older. All study participants will be vaccinated with the licenced inactivated TBE vaccine (FSME-IMMUN). Vaccination efficacy will be monitored longitudinally by assessing TBE virus-specific antibody (TBEV-specific ELISA, TBEV-specific neutralization), TBE virus-specific B memory cell response (ELISpot) and TBE virus-specific T cell response (cytokine production). Vaccination efficacy will be compared among the two age groups one month after each vaccination and three months after the second and third vaccination, respectively.

Critère d'inclusion

• This study will investigate immunity against tick-borne encephalitis (TBE) following primary TBE vaccination in healthy volunteers 18-30 years or > 60 years who fulfill the local criteria for TBE vaccination (tick exposure possible)

Liens

• ictrp
• euctr