Femme et Homme
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Extrait
Primary Objective Phase I: •To determine the safety of matuzumab in combination with erlotinib in up to 5 different dose cohorts. Primary Objective Phase II: •To determine the tumor response rate (RR; defined as complete response [CR] plus partial response [PR]) of matuzumab in combination with erlotinib, at a single dose chosen from phase I, according to the modified World Health Organization (WHO) criteria as assessed by an Independent Review Committee (IRC).
Critère d'inclusion
- Stage IIIB/IV non-small cell lung cancer and progressive disease after first-line treatment with a platinum analogue in comination with taxanes, gemcitabine, or vinorelbine