Extrait

1.Evaluation of efficacy of the following two treatments for usual type VIN: -Vaccination + imiquimod: Vaccination with Gradasil, followed by local applications of imiquimod 5% cream. -Imiquimod alone: Placebo vaccination (saline) followed by local applications of imiquimod 5% cream. 2.Evaluation of the systemic and local immunological response to both treatments. 3.Evaluation of the effect of treatments on HPV DNA presence in VIN lesions, by comparison of Polymerase Chain Reaction (PCR) HPV-DNA detection in vulvar biopsies taken at 0 and 36 weeks.

Critère d'inclusion

• In this trial, the efficacy of Gardasil combined with imiquimod in women with usual type Vulvar Intraepithelial Neoplasia is investigated

Liens

• ictrp
• euctr