A Randomized Clinical Trial to Evaluate the Effects of High Dose Statin and Niacin Therapy on Excised Plaque Biomarkers in Patients Undergoing Carotid Endarterectomy (CEA)

Mise à jour : Il y a 4 ans
Référence : EUCTR2008-008006-46

Femme et Homme

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Extrait

To determine whether 4 to 12 weeks of treatment with atorvastatin 80 mg/day + niacin ER 2 g/day compared to low dose atorvastatin 10 mg/day will result in a difference in the following endpoints: (1) Composite score of “plaque inflammation/stability” gene expression as assayed by RNA Taqman analysis (referred to as “Hot/Cold” RNA biomarker panel); (2) Plaque Instability Protein Composite Score; (3) Cholesterol content.


Critère d'inclusion

  • Carotid Atherosclerosis