Femme et Homme
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Extrait
Stage 1 (i) What are the pharmacokinetics of 50mg and 100mg oral melatonin in patients with sepsis? (ii) Which dose is most suitable based on the pharmacokinetics in (i)? (iii) What is the most suitable dosing interval based on results from (i)? Stage 2 (iv) What effect does oral melatonin have on the defined outcome measures compared to placebo? (v) What effects does melatonin have on mRNA expression under conditions of sepsis?
Critère d'inclusion
- Sepsis